In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity.
In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity.
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红色：免疫调节缺陷是银屑病严重程度的基础。
DOI：
10.1016/j.jid.2016.08.008
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Johnston,Andrew
中科院分区：
文献类型：
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作者：
Johnston,Andrew
白介素17驱动的通路在银屑病患者的皮肤中是活跃的。Kim等人。检查了轻度和中度到重度银屑病的皮损，发现皮肤病严重程度的差异可能是免疫调节机制失误的结果；因为在轻度银屑病中发现同样多(如果不是更多)辅助性T细胞17诱导的炎症，这些患者也可能受益于抗IL-17靶向生物制剂。
IL-17–driven pathways are active in the skin of patients with psoriasis. Kim et al. examined lesions from mild and moderate to severe psoriasis and found that differences in cutaneous disease severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not more, T helper type 17–induced inflammation was seen in mild psoriasis, these patients may also benefit from anti-IL-17–targeted biologics.