Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis
Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis
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DOI：
10.1016/j.jns.2005.03.018
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发表时间：
2005-06-15
影响因子：
4.4
通讯作者：
Federico, A
中科院分区：
文献类型：
--
作者：
De Stefano, N;Bartolozzi, ML;Federico, A
最近的MR研究强调了神经元和轴突损伤在多发性硬化中的重要性。在这方面，质子磁共振波谱（通过监测N-乙酰天冬氨酸水平，轴突完整性的一个假定的标志物）已特别说明，从疾病的最早阶段显示病变和非病变脑组织中的神经变性的间接证据。这些变化对患者临床残疾的重要性证明了神经元病理在疾病发病机制中的主要作用。(c)2005 Elsevier B. V.保留所有权利。
Recent MR studies have emphasised the importance of neuronal and axonal damage in multiple sclerosis. In this respect, proton MR spectroscopy (by monitoring levels of N-acetylaspartate, a putative marker of axonal integrity) has been particularly illuminating by showing indirect evidence of neurodegeneration in both lesional and non-lesional brain tissues from the earliest stages of the disease. The importance of these changes to patients' clinical disability argues for the primary role of neuronal pathology in the pathogenesis of the disease. (c) 2005 Elsevier B.V. All rights reserved.