Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators
Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators
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DOI：
10.1021/nl101107u
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发表时间：
2010-07-01
期刊：
影响因子：
10.8
通讯作者：
Manalis, Scott R.
中科院分区：
文献类型：
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作者：
Lee, Jungchul;Shen, Wenjiang;Manalis, Scott R.
使用悬浮纳米通道谐振器(SNR)，我们展示了在1 kHz带宽内以27ag的分辨率测量溶液中的质量，这代表着比现有的悬浮微通道谐振器提高100倍，据我们所知，这是当今液体中最精确的质量测量。SNR由一个长50微米、宽10微米、厚1.3微米的悬臂组成，其中嵌入一个宽2微米、高700纳米的纳米通道。SNR的共振频率接近630 kHz，在干燥和充满水时显示出大约8000的品质因数，此外，介绍了一种利用悬臂梁振动产生的离心力在自由端捕获粒子的新方法。该方法消除了信噪比固有的位置依赖误差，并通过增加每个粒子的平均时间来提高质量分辨率
Using suspended nanochannel resonators (SNRs), we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today The SNR consists of a cantilever that is 50 mu m long, 10 mu m wide, and 1 3 mu m thick, with an embedded nanochannel that is 2 mu m wide and 700 nm tall The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8000 when dry and when filled with water In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle