Adverse effects of sympathetic activation should not be neglected during the coronavirus disease 2019 pandemic.
Adverse effects of sympathetic activation should not be neglected during the coronavirus disease 2019 pandemic.
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2019 年冠状病毒病大流行期间，不应忽视交感神经激活的不利影响
DOI：
10.1097/cm9.0000000000001106
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发表时间：
2020-09-14
影响因子：
6.1
通讯作者：
Wu YM
中科院分区：
文献类型：
--
作者：
Jin S;Dai J;Teng X;Wu YM
正在进行的2019冠状病毒病（COVID-19）大流行在全球造成了相当高的发病率和死亡率。此外，受感染的人数正在迅速上升。该病由属于b型冠状病毒簇的严重急性呼吸综合征冠状病毒2 （SARSCoV-2）引起；这类病毒还包括引起严重急性呼吸窘迫综合征（SARS）和中东呼吸综合征的病毒。与sars冠状病毒（CoV）类似，SARSCoV-2利用血管紧张素转换酶2 （ACE2）侵入其靶细胞；然而，SARS-CoV-2对ACE2具有更高的结合亲和力。因此，与可以有效控制的sars - cov不同，SARS-CoV-2的传染性更强，难以控制。
The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in considerable morbidity and mortality worldwide. Furthermore, the number of infected individuals is rising rapidly. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) belonging to the b-coronavirus cluster; this cluster also comprises the viruses causing severe acute respiratory distress syndrome (SARS) and Middle East respiratory syndrome. Similar to SARS-coronavirus (CoV), SARSCoV-2 exploits angiotensin-converting enzyme 2 (ACE2) to invade its target cells; however, SARS-CoV-2 has a higher binding affinity for ACE2. Therefore, unlike SARSCoV, which can be efficiently contained, SARS-CoV-2 is more infectious and difficult to control.