SPECIFIC EPSTEIN-BARR VIRUS SEROLOGICAL RESPONSE IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA DETECTED BY IMMUNOBLOTTING
SPECIFIC EPSTEIN-BARR VIRUS SEROLOGICAL RESPONSE IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA DETECTED BY IMMUNOBLOTTING
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DOI：
10.1007/bf00148913
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发表时间：
1988-09-01
影响因子：
13.6
通讯作者：
LAPLACA, M
中科院分区：
文献类型：
--
作者：
CEVENINI, R;DONATI, M;LAPLACA, M
应用免疫印迹技术，比较了鼻咽癌（NPC）、传染性单核细胞增多症（IM）和其他EB病毒（EBV）血清阳性者的特异性体液免疫应答。几乎所有的血清EBV血清学相关的NPC反应可重复与早期抗原（EA）复合物的分子量范围从50 kD到58 kD的主要组的多肽（4至6），并与一些额外的多肽。来自IM患者的血清可重复地识别属于EA复合物的主要多肽组的50 kD的多肽。来自其他类型的头颈癌和相对高水平的抗病毒衣壳抗原（VCA）和EA的IgG抗体的患者的血清与任何EBV相关蛋白没有可重复的反应。
The specific humoral immune response against Epstein-Barr virus (EBV) antigens in patients with nasopharyngeal carcinoma (NPC) was compared to that of patients with infectious mononucleosis (IM) and other EBV-seropositive subjects using immunoblotting technique. Almost all sera from EBV serologically associated NPC reacted reproducibly with a major group of polypeptides (four to six) of early antigen (EA) complex with molecular weights ranging from 50 kD to 58 kD, and with some additional polypeptides. Sera from IM-patients reproducibly recognized only one polypeptide of 50 kD belonging to the major group of polypeptides of EA-complex. Sera from patients with other types of head and neck cancer and relatively high levels of IgG antibody against viral capsid antigen (VCA) and EA did not react reproducibly with any of the EBV-associated proteins.