Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients
Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients
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DOI：
10.1016/j.parkreldis.2012.05.022
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发表时间：
2012-11-01
影响因子：
4.1
通讯作者：
Barone, Paolo
中科院分区：
文献类型：
--
作者：
Erro, Roberto;Pappata, Sabina;Barone, Paolo
背景：焦虑是帕金森病（PD）患者常见的非运动症状。虽然帕金森病患者焦虑的病因可能是多因素的，但多巴胺能系统功能障碍可能与其发病机制有关。本研究的目的是探讨一种可能的多巴胺能机制参与焦虑的新诊断的从未使用药物的PD患者使用SPECT和I-123-FP-CIT作为多巴胺转运ligand.Methods：34个新诊断的，未经治疗的PD患者的不对称运动症状包括在研究中：17例右侧和17例左侧运动发作的患者，年龄，病程和运动障碍相匹配。他们都进行了焦虑和抑郁的评估，并进行了SPECT与I-123-EP-CIT。计算左右尾状核和壳核的多巴胺转运蛋白（DAT）可用性值，并比较有焦虑和无焦虑患者之间的差异。回归分析也进行了相关的DAT可用性与焦虑symptoms.Results的严重程度：PD患者与那些没有焦虑之间的比较显示，除右壳核的DAT可用性在所有检查区域的显着差异。在组的患者被认为是一个整体，一个显着的相关性之间增加焦虑的严重程度和减少DAT的可用性在right caudate.Conclusions：我们报告了黑质纹状体DAT的可用性赤字和焦虑症状之间的关联在新诊断的，未经治疗的PD患者。我们的研究结果表明，黑质纹状体多巴胺能系统的功能减退可能代表一个功能异常参与焦虑的PD从疾病的最早阶段，无论任何治疗。(C)2012爱思唯尔有限公司保留所有权利。
Background: Anxiety is a common non-motor symptom among patients with Parkinson's disease (PD). Although the etiology of anxiety in PD is likely to be multifactorial, a dysfunction in the dopaminergic system might be implicated in its pathogenesis. The aim of our study was to investigate a possible dopaminergic mechanism involved in anxiety in newly diagnosed never-medicated PD patients using SPECT and I-123-FP-CIT as the dopamine transporter ligand.Methods: Thirty-four newly diagnosed, untreated PD patients with asymmetric motor symptoms were included in the study: 17 patients with right- and 17 with left-motor onset, matched for age, disease duration and motor disability constituted the group. They were all evaluated for anxiety and depression and underwent an SPECT with I-123-EP-CIT. Dopamine transporter (DAT) availability values for right and left caudate and putamen were calculated and compared between patients with and without anxiety. Regression analyses were also performed in order to correlate DAT availability with the severity of the anxiety symptoms.Results: Comparison between PD patients with and those without anxiety revealed significant differences of DAT availability in all the examined regions except the right putamen. In the group of patients considered as a whole, a significant correlation was found between increased anxiety severity and decreased DAT availability in right caudate.Conclusions: We reported an association between nigrostriatal DAT availability deficits and anxiety symptoms in newly diagnosed, untreated PD patients. Our results suggest that hypofunction of the nigrostriatal dopaminergic system may represent one of the functional anomalies involved in anxiety in PD from the earliest stages of disease and irrespective of any therapy. (C) 2012 Elsevier Ltd. All rights reserved.