The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes In Rectal Cancer.
The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes In Rectal Cancer.
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DOI：
10.1007/s11888-017-0351-z
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发表时间：
2017-03
影响因子：
--
通讯作者：
Jabbour SK
中科院分区：
文献类型：
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作者：
Hathout L;Williams TM;Jabbour SK
三维适形放射治疗（3DCRT）已成为治疗直肠癌的标准技术。过去 10 年来，调强放射治疗 (IMRT)、质子治疗 (PT)、立体定向放射治疗 (SBRT) 和近距离放射治疗 (BT) 等新型放射治疗技术的使用不断增加。这篇评论将重点介绍这些技术的优点和缺点。与 3DCRT 相比，IMRT、PT、SBRT 和 BT 实现了更高的靶区覆盖一致性、更高的风险器官保护并能够增加剂量。一些研究表明，胃肠道和血液毒性降低，完全病理缓解率提高；然而，这些技术的临床益处仍然存在争议。尽管有确凿的数据，但这些新技术的结果似乎令人鼓舞。需要进一步的试验来确定它们在直肠癌中的作用。
Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT) and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. IMRT, PT, SBRT and BT achieve a higher target coverage conformity, a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggested a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.