HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
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DOI：
10.1016/s0014-5793(01)02945-3
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发表时间：
2001-10-19
期刊：
影响因子：
3.5
通讯作者：
Hübscher, U
中科院分区：
文献类型：
--
作者：
Tasara, T;Maga, G;Hübscher, U
有序的分子相互作用和结构变化必须发生在人类免疫缺陷病毒1型（HIV-1）整合前复合物的各个阶段，以成功的病毒复制。我们证明了HIV-1逆转录酶和整合酶之间的物理和生物化学相互作用。这种相互作用可能对两种酶在HIV-1复制复合物中的体内功能有影响。它可能是促进HIV-1在靶细胞内有效复制的各种分子相互作用之一。(C)2000年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzyme; within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.