Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
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中国云南省早发精神分裂症的病程、结果和诊断稳定性——一项三年随访研究
DOI：
10.1016/j.psychres.2018.11.013
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发表时间：
2019-01-01
影响因子：
11.3
通讯作者：
Srihari, Vinod H.
中科院分区：
文献类型：
--
作者：
Kang Chuanyuan;Zhou Huizhi;Srihari, Vinod H.
这项研究的目的是描述早发性精神分裂症(EOS)患者的诊断稳定性和心理社会结果。研究对象为2011-01/2015-07在昆明医科大学附属第一医院精神科住院，符合国际疾病分类-10精神分裂症诊断标准，出院12个月以上的受试者。迷你国际神经精神病学访谈用于终生ICD-10诊断，个人和社会表现(PSP)用于全球功能评估。共随访249例，其中101例获得随访，脱落率为59.4%。平均37.2+/-16.2个月后，92例患者(包括1例死亡)仍符合ICD-10精神分裂症诊断标准(F20)。在总体功能方面，48.5%的患者预后良好，43.6%的患者预后良好，7.9%的患者预后不良。在本研究中，ICD-10定义的精神分裂症的诊断稳定性相对较高。此外，我们的结果对EOS的结果描绘了比以前从西方国家报道的更乐观的图景。
The aim of the study was to describe diagnostic stability and psychosocial outcomes of subjects with early-onset schizophrenia (EOS). All the subjects who had been hospitalized in the Department of Psychiatry of the First Affiliated Hospital of Kunming Medical University between January 2011 and July 2015 with the diagnosis of International Classification of Diseases (ICD)-10 defined schizophrenia, and discharged from the hospital for more than 12 months were enrolled to the study. The Mini International Neuropsychiatric Interview was applied for life-time ICD-10 diagnoses, and Personal and Social Performance (PSP) for global function evaluation. Altogether 249 patients were targeted for follow-up, in which 101 were followed up and the dropout rate was 59.4%. After average 37.2 +/- 16.2 months, 92 patients (including 1 death) were still met the ICD-10 diagnosis of schizophrenia (F20). In terms of global functioning, 48.5% of patients had good outcome, 43.6% had moderate outcome, and 7.9% had poor outcome. A relatively high diagnostic stability of ICD-10 defined schizophrenia was obtained in the current study.Moreover, our results draw a much more optimistic picture of the outcome for EOS than what has previously been reported from Western counties.