Sexual dimorphism and asymmetry in human cerebellum: An MRI-based morphometric study
Sexual dimorphism and asymmetry in human cerebellum: An MRI-based morphometric study
复制标题
人类小脑的性别二态性和不对称性：基于 MRI 的形态测量研究
DOI：
10.1016/j.brainres.2010.07.031
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发表时间：
2010-09-24
期刊：
影响因子：
2.9
通讯作者：
Liu, Shuwei
中科院分区：
文献类型：
--
作者：
Fan, Lingzhong;Tang, Yuchun;Liu, Shuwei
人类小脑的结构性二态性和不对称性已在先前的研究中描述，但结果仍然是不确定的，甚至相互矛盾。在这项研究中，性别差异和大脑半球的不对称性，全球和区域人类小脑灰质（GM）估计在一个年龄匹配的样本（n=112）的年轻中国成年人。一个优化的基于体素的形态测量（VBM）在空间无偏幕下模板（SUIT）空间与自动化的atlas为基础的体积方法进行映射区域灰质（GM）的性别相关的差异在整个小脑。这两种方法提供了一致的结果，性别差异。男性组小脑GM体积在前、中后叶明显增大。此外，观察到雌性组外侧后叶GM体积增大的趋势。利用建立的对称小脑模板，通过VBM分析评价小脑半球的不对称性，发现小脑半球的不对称性主要分布在小脑小叶的内侧，而小脑半球的不对称性主要分布在小脑后叶的内侧。与女性相比，男性的性别差异表现为在少数小叶内稀疏的高水平不对称性和主要在小叶脚II内的低水平不对称性。正常人小脑的形态学知识可以建立一个基线，以比较小脑的病理变化。此外，我们的研究结果可能有助于解决人类小脑性别二态性和不对称模式研究中的争议。(C)2010 Elsevier B.V.保留所有权利。
Structural sexual dimorphism and asymmetry in human cerebellum have been described in previous research, but results remain inconclusive or even conflicting. In this study, gender differences and hemispheric asymmetries in global and regional human cerebellum gray matter (GM) were estimated in an age-matched sample (n=112) of young Chinese adults. An optimized voxel-based morphometry (VBM) in spatial unbiased infratentorial template (SUIT) space together with an automated atlas-based volumetric approach were performed for mapping regional gray matter (GM) gender-related differences across the entire cerebellum. The two methods provided consistent findings on gender differences. The cerebellar GM volume was significantly larger in the anterior and middle posterior lobes of male group. In addition, a trend of greater GM volume in lateral posterior lobe of female group was observed. With the created symmetric cerebellar template, the asymmetric properties of cerebellar hemisphere were also assessed by VBM analysis, showing rightward asymmetry distributed in most cerebellar lobules and leftwards asymmetry distributed in the lobules around the medial posterior lobe. Gender differences in males showed higher leftward asymmetry sparsely within a few lobules and lower rightward asymmetry mainly within lobule Crus II, as compared with females. The acquired detailed morphologic knowledge of normal human cerebellum could establish a baseline for comparison with pathologic changes in the cerebellum. Moreover, our results might help to address controversies in the study of sexual dimorphisms and asymmetric patterns in human cerebellum. (C) 2010 Elsevier B.V. All rights reserved.