LEUKOTRIENE C-4 AND D4 IN NEONATES WITH HYPOXEMIA AND PULMONARY-HYPERTENSION
LEUKOTRIENE C-4 AND D4 IN NEONATES WITH HYPOXEMIA AND PULMONARY-HYPERTENSION
复制标题
DOI：
10.1056/nejm198307143090204
复制
发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
MURPHY, RC
中科院分区：
文献类型：
--
作者：
STENMARK, KR;JAMES, SL;MURPHY, RC
新生儿持续性肺动脉高压是一种由严重低氧血症和肺动脉高压组成的综合征，在出生后数小时内出现。由于某些白三烯（C4，D4和E4）产生新生儿持续性肺动脉高压的一些特征，包括肺血管收缩，支气管收缩，肺顺应性下降和肺水肿，5名新生儿与综合征进行了研究，以确定这些白三烯是否存在于他们的气道。在所有5名临床诊断为持续性肺动脉高压并需要辅助治疗的新生儿的肺灌洗液中发现了白三烯C4和白三烯D4。对照组14名没有持续性肺动脉高压临床诊断的需要辅助治疗的婴儿中没有发现白三烯。白三烯可能在新生儿持续性肺动脉高压中起作用。
Persistent pulmonary hypertension of the newborn is a syndrome consisting of severe hypoxemia and pulmonary hypertension that appears within hours of birth. Since certain leukotrienes (C4, D4 and E4) produce some of the features of persistent pulmonary hypertension of the newborn, including pulmonary vasoconstriction, bronchoconstriction, decreased lung compliance and pulmonary edema, 5 newborns with the syndrome were studied to determine whether these leukotrienes were present in their airways. Leukotriene C4 and leukotriene D4 were found in the lung lavage fluids of all 5 newborns who had the clinical diagnosis of persistent pulmonary hypertension and who required ventilatory assistance. Leukotrienes were not demonstrated in a control group of 14 infants requiring ventilatory assistance who did not have the clinical diagnosis of persistent pulmonary hypertension. Leukotrienes may have a role in persistent pulmonary hypertension of the newborn.