Non-linear relationships between children age and pneumococcal vaccine coverage: Important implications for vaccine prevention strategies
Non-linear relationships between children age and pneumococcal vaccine coverage: Important implications for vaccine prevention strategies
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DOI：
10.1016/j.vaccine.2021.01.056
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发表时间：
2021-02-13
期刊：
影响因子：
5.5
通讯作者：
Ye，Xiaohua
中科院分区：
文献类型：
--
作者：
Liu，Yanling;Li，Wenhui;Ye，Xiaohua
肺炎链球菌是引起儿童侵袭性和非侵袭性感染的重要病原菌，在世界范围内具有重要的发病率和死亡率。这项研究旨在确定年龄和疫苗覆盖率之间的潜在关系，以及OFS的多种表型-基因型特征之间的潜在关系。从儿童分离的肺炎。对肺炎分离株进行了药物敏感性、毒力基因、血清型和序列类型的测试。结果在胶囊型疫苗中，我们观察到13价肺炎球菌结合疫苗的接种率很高(PCV13，85.8%)，儿童年龄与疫苗接种率(包括PCV7、PCV10和PCV13)之间存在显著的非线性关系，2岁和2岁的儿童有明显的波动。对于基于蛋白质和菌毛的候选疫苗，我们展示了年龄和疫苗覆盖率之间的动态非线性关系，保持了所有年龄组的PlyandlytA的稳定和高覆盖率。此外，多个表型-基因型特征之间存在显著的高维对应关系。肺炎分离株(如与19F、PI-2和广泛耐药相关的ST271)。结论我们的研究结果表明，PCV高覆盖率的年龄是2岁以下的≥儿童，也为支持PlyandlytA作为新一代蛋白疫苗开发的优先候选靶点提供了重要证据。
BackgroundStreptococcus pneumoniae (S. pneumoniae) is an important pathogen causing both invasive and non-invasive infections in children, with significant morbidity and mortality worldwide. This study aimed to determine the potential relationships between age and vaccine coverage and between multiple phenotype-genotype characteristics ofS. pneumoniaeisolated from children.MethodsAllS. pneumoniaeisolates were tested for antimicrobial susceptibility, virulence genes, serotypes, and sequence types. The restricted cubic spline models were used to reveal potential relationships between children age and pneumococcal vaccine coverage.ResultsFor capsular-based vaccines, we observed a high coverage rate of 13-valent pneumococcal conjugate vaccine (PCV13, 85.8%) and a significantly non-linear relationship between children age and vaccine coverage (including PCV7, PCV10, and PCV13), with marked fluctuations in children aged < 2 years. For protein-based and pilus-based vaccine candidates, we demonstrated dynamic non-linear relationships between age and vaccine coverage, maintaining a stable and high coverage rate ofplyandlytAfor all age groups. Moreover, there were significantly high-dimensional corresponding relationships among multiple phenotype-genotype characteristics ofS. pneumoniaeisolates (such as ST271 associated with serotype 19F, PI-2, and extensively drug-resistance).ConclusionsOur findings suggest that the age for high PCV coverage being children aged ≥ 2 years and also provide important evidence for supportingplyandlytAas priority candidate targets for the development of new-generation protein vaccines.