Circadian effectiveness of two polychromatic lights in suppressing human nocturnal melatonin
Circadian effectiveness of two polychromatic lights in suppressing human nocturnal melatonin
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DOI：
10.1016/j.neulet.2006.07.069
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发表时间：
2006-10-09
影响因子：
2.5
通讯作者：
Bullough, John D.
中科院分区：
文献类型：
--
作者：
Figueiro, Mariana G.;Rea, Mark S.;Bullough, John D.
40名受试者参加了一项研究，以测试最近的人体昼夜节律光转导模型的准确性，用于预测两种多色光源抑制夜间褪黑激素的相对有效性。使用了短暂暴露于四种不同的光水平（角膜30、100、300和1000明视勒克斯）和两种不同的“白色”灯光谱（4100和8000 K）。结果表明，该模型可以正确地订购的两个昼夜节律刺激的相对幅度，但夜间褪黑激素抑制遵循的速率限制的光的反应，不能预测从单独的抑制光刺激的幅度。这些结果的一些实际意义进行了讨论。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Forty subjects participated in a study to test the accuracy of a recent model of human circadian phototransduction for predicting the relative effectiveness of two polychromatic light sources at suppressing nocturnal melatonin. Brief exposures to four different light levels (30, 100, 300 and 1000 photopic lux at the cornea) and two different "white" lamp spectra (4100 and 8000 K) were used. Results suggest that the model can properly order the relative magnitudes of the two circadian stimuli, but that nocturnal melatonin suppression follows a rate-limited response to light that cannot be predicted from the magnitude of the suppressing light stimulus alone. Some practical implications of these results are discussed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.