Engineering 2D multifunctional ultrathin bismuthene for multiple photonic nanomedicine
Engineering 2D multifunctional ultrathin bismuthene for multiple photonic nanomedicine
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用于多光子纳米医学的工程二维多功能超薄铋
DOI：
10.1002/adfm.202005093
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发表时间：
2020
影响因子：
19
通讯作者：
Shi Jianlin
中科院分区：
文献类型：
--
作者：
Wang Yuemei;Feng Wei;Chang Meiqi;Yang Jiacai;Guo Yuedong;Ding Li;Yu Luodan;Huang Hui;Chen Yu;Shi Jianlin
二维单元素纳米材料（Xenes）在多种生物医学应用方面显示出巨大的潜力。铋作为致烟原中的重元素，因其独特的光学性能、较高的生物相容性、稳定性和相对较低的成本而引起了广泛的研究兴趣。然而，二维铋在纳米医学中的应用尚未实现，因为具有关键结构/组成特征的铋难以满足严格的生物医学要求。为了解决这个难题，我们提出了一种简单的策略，通过水分子介导的冻融过程和硼氢化钠触发的还原处理来插入和分层铋体，从而产生高产量的大质量少层二维铋。由此产生的二维铋在近红外（NIR）生物窗口中显示出良好的光学性能，并且可以通过红光激发以产生活性氧，从而可以应用于多种光子癌症纳米医学设置，包括光热热疗和光动力疗法。利用铋固有的理想光学吸收和强X射线衰减，双光子治疗可以在光声/计算机断层扫描引导的多模态成像的监督下进行。这项研究不仅提供了一种潜在的大规模生产准备，成本效益和生态效益的工程2D氙气的方法，而且还开发了一种创新的基于二维铋的光子癌症纳米药物。
2D monoelemental nanomaterials (Xenes) have shown tremendous potential for versatile biomedical applications. Bismuth, as a heavy element in pnictogens, has acquired massive research interest due to its unique optical performance, high biocompatibility, stability, and relatively low cost. However, the utilization of 2D bismuthene in nanomedicine has not been achieved because of the difficulty in engineering bismuthene with crucial structural/compositional characteristics for satisfying strict biomedical requirements. Herein, to address this Gordian knot, a facile strategy to intercalate and delaminate Bi bulk for generating mass few‐layered 2D bismuthene with high yield by employing a water molecule mediated freezing–thawing process and sodium borohydride‐triggered reduction treatment is proposed. The resulting 2D bismuthene displays good optical performance in the near‐infrared (NIR) biowindow and can be excited via red light for reactive oxygen species generation, enabling applications in multiple photonic cancer nanomedicine settings, including photothermal hyperthermia and photodynamic therapy. Utilizing the intrinsic desirable optical absorbance and strong X‐ray attenuation of bismuthene, dual photonic therapy can be conducted under the supervision of photoacoustic/computed tomography guided multimodal imaging. This research not only offers a potential mass‐production ready, cost‐effective, and eco‐efficient methodology for engineering 2D Xenes, but also exploits an innovative 2D bismuthene based photonic cancer nanomedicine.