Dexamethasone protects the hearing of Meniere's disease patients after triple semicircular canal plugging
Dexamethasone protects the hearing of Meniere's disease patients after triple semicircular canal plugging
复制标题
地塞米松对三联半规管封堵后梅尼埃病患者听力的保护作用
DOI：
10.1080/00016489.2020.1775292
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发表时间：
2020-06-18
影响因子：
1.4
通讯作者：
Wang, Haibo
中科院分区：
文献类型：
--
作者：
Lyu, Yafeng;Zhang, Daogong;Wang, Haibo
背景：TSCP显示了其在眩晕控制中的疗效，对棘手的Meniere病。但是，听力障碍仍然是一个问题，并阻碍了手术的应用。目的/目标：调查地塞米松对TSCP后Meniere病患者的听力的影响，以确定炎症是否参与了此过程材料和方法：术后有或没有地塞米松治疗的TSCP手术的Meniere病患者。在手术后2年的随访中评估了所有患者的听力功能，并在两组之间进行了比较。结果：与非塞米松组相比，地塞米松组的听力恶化和单词识别评分损失比非塞米松组更轻。即使在手术两年后，地塞米松组的强烈听力恶化和单词识别评分损失的损失仍然明显低于非塞米松组。结论：地塞米松保护了TSCP后Meniere患者的听力。 TSCP可能导致这些患者听力障碍的机制可能涉及炎症。意义：这一发现表明，TSCP后应常规使用类固醇来保存听力，并且需要修改手术先例以最大程度地减少内耳的炎症。
Background:TSCP has shown its efficacy in vertigo control for intractable Meniere's disease. However, hearing impairment remains a problem and hampered the application of the surgery. Aims/objectives:To investigate the effect of dexamethasone on the hearing of Meniere's disease patients after TSCP to determine whether inflammation is involved in this process Material and methods:Meniere's disease patients who received TSCP surgeries were treated with or without dexamethasone postoperatively. All patients' hearing function were evaluated during a follow up of 2 years after surgery and compared between the two groups. Results:Hearing worsening and word recognition score loss were milder in the dexamethasone group than in the non-dexamethasone group. The rates of profound hearing worsening and word recognition score loss remained significantly lower in the dexamethasone group than in the non-dexamethasone group even 2 years after surgery. Conclusions:Dexamethasone protects the hearing of Meniere's patients after TSCP. Inflammation may be involved in the mechanism by which TSCP causes hearing impairment in these patients. Significance:This finding suggests that steroids should be used routinely after TSCP for hearing preservation, and operative precedures need to be modified to minimize inflammation in the inner ear.