RNA polymerase II holoenzyme and transcriptional regulation
RNA polymerase II holoenzyme and transcriptional regulation
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DOI：
10.1016/s0955-0674(97)80002-6
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发表时间：
1997-06-01
影响因子：
7.5
通讯作者：
Greenblatt, J
中科院分区：
文献类型：
--
作者：
Greenblatt, J
从酵母和哺乳动物细胞中分离的RNA聚合酶II全酶是大的、预组装的复合物，其含有一些或全部的一般转录起始因子和许多其它多肽。最近的实验表明，这些全酶可能介导染色质结构的改变，并在影响转录起始、RNA链延伸、RNA加工和转录终止的调控机制中发挥关键作用。
RNA polymerase II holoenzymes isolated from yeast and mammalian cells are large, preassembled complexes that contain some or all of the general transcription initiation factors and many other polypeptides. Recent experiments suggest that these holoenzymes may mediate alterations in chromatin structure and play a key role in regulatory mechanisms that influence transcriptional initiation, RNA chain elongation, RNA processing and transcription termination.