Development of hyperactivity after acoustic trauma in the guinea pig inferior colliculus
Development of hyperactivity after acoustic trauma in the guinea pig inferior colliculus
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DOI：
10.1016/j.heares.2012.12.008
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发表时间：
2013-04-01
期刊：
影响因子：
2.8
通讯作者：
Robertson, D.
中科院分区：
文献类型：
--
作者：
Mulders, W. H. A. M.;Robertson, D.
通过单侧声损伤豚鼠下丘（IC）单神经元记录，研究了多活动的发生时间（自发放电率增加）。听伤后12小时出现多动症，而在听伤停止后约4小时内获得的数据未发现多动症的证据。这些数据表明，耳蜗损伤后4至12小时的某个时间内，耳蜗内的多动开始，是一个相对快速的可塑性事件，在几小时内而不是几天内开始。这与猫听觉皮层的研究结果一致（Norena和Eggermont， 2003）。在听觉创伤后12小时至2周内，多动症没有显示任何进一步的系统性增加。在12和24小时的恢复时间内，过度活跃在IC的大多数区域广泛存在，但在更长的恢复时间内，它逐渐局限于耳蜗持续损伤区域对应的腹侧区域。(C) 2012 Elsevier B.V.版权所有
The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10 kHz tone). Hyperactivity was present by 12 h post acoustic trauma whereas data obtained within approximately 4 h of the cessation of acoustic trauma found no evidence of hyperactivity. These data suggest that hyperactivity in the IC begins at some time between 4 and 12 h post trauma and is a relatively rapid plastic event beginning within hours rather than days post cochlear trauma. This is consistent with results reported in the cat auditory cortex (Norena and Eggermont, 2003). Hyperactivity did not show any further systematic increase between 12 h and up to 2 weeks post acoustic trauma. At recovery times of 12 and 24 h hyperactivity was widespread across most regions of the IC but at longer recovery times, it became progressively more restricted to ventral regions corresponding to the regions of the cochlea where there was persistent damage. (C) 2012 Elsevier B.V. All rights reserved.