Serum FABP1 Levels Correlate Positively with Obesity in Chinese Patients After Laparoscopic Sleeve Gastrectomy: a 12-Month Follow-up Study.
Serum FABP1 Levels Correlate Positively with Obesity in Chinese Patients After Laparoscopic Sleeve Gastrectomy: a 12-Month Follow-up Study.
复制标题
腹腔镜袖状胃切除术后中国患者血清 FABP1 水平与肥胖呈正相关：一项 12 个月的随访研究。
DOI：
10.1007/s11695-019-04307-3
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发表时间：
2020
期刊：
影响因子：
2.9
通讯作者：
Qu Shen
中科院分区：
文献类型：
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作者：
You Hui;Wen Xin;Zhu Cuiling;Chen Ming;Dong Liting;Zhu Yanli;Yang Liu;Bu Le;Zhang Manna;Zhou Donglei;Lu Liesheng;Du Lei;Lin Ziwei;Qu Shen
肝脏脂肪酸结合蛋白（FABP 1）在肥胖中的作用目前尚不清楚。我们调查了中国人群中FABP 1与肥胖的相关性以及腹腔镜袖状胃切除术（LSG）后观察到的变化。方法横断面分析包括187名个体：65名体重正常（18.5 ≤体重指数（BMI）< 24 kg/m2），59名超重（24 ≤ BMI < 28 kg/m2），63名肥胖（BMI ≥ 28 kg/m2）。我们还评估了25名严重肥胖患者，观察肥胖组（BMI为38.58 ± 4.59 kg/m2）及LSG后3、6、12个月的FABP 1水平。（30.33 ± 23.59 ng/ml，** P <0.01，*P< 0.001）和超重（18.96 ± 18.75 ng/ml，P= 0.471）者显著高于正常体重（14.30 ± 9.37 ng/ml）者。线性回归分析显示，FABP 1水平与BMI呈正相关（R2= 0.201，*P< 0.001），ALT（R2= 0.324，*P< 0.001），AST（R2= 0.387，*P< 0.001），m-AST（R2= 0.160，*P< 0.001），γ-GT（R2= 0.106，*P< 0.001），DBil（R2= 0.078，*P< 0.001），UA相关分析显示，高密度脂蛋白（HDL）、空腹血糖（FBG）、低密度脂蛋白（LDL）与高密度脂蛋白（HDL）呈负相关（R2 = 0.051，** P = 0.002）。校正年龄、性别、ALT、AST、TC、TG、HDL、LDL、FBG和UA后，FABP 1与BMI独立相关（*P< 0.05）。随着LSG后BMI的降低，FABP 1水平（29.46 ± 21.19 ng/ml，P= 0.463，P = 0.06，P< 0.05）（23.00 ± 22.77 ng/ml），6（14.41 ± 15.48）ng/ml，12个月（11.55 ± 3.27 ng/ml）。结论血清FABP 1水平与肥胖及多种代谢因素密切相关，随着LSG后BMI的降低，术后FABP 1水平也逐渐降低。试验RegistrationClinicalTrials.gov标识符：ChiCTR-OCS-12002381
ObjectiveThe role of liver fatty acid-binding protein (FABP1) in obesity is presently unclear. We investigated the association of FABP1 with obesity and the changes noted after laparoscopic sleeve gastrectomy (LSG) in a Chinese population.MethodsThe cross-sectional analysis included 187 individuals: 65 had normal weight (18.5 ≤ body mass index (BMI) < 24 kg/m2), 59 were overweight (24 ≤ BMI < 28 kg/m2), and 63 were obese (BMI ≥ 28 kg/m2). We also assessed 25 severely obese patients (BMI, 38.58 ± 4.59 kg/m2) at baseline and at 3, 6, and 12 months after LSG to observe FABP1 levels.ResultsFABP1 levels in the obese (30.33 ± 23.59 ng/ml, **P< 0.01, ***P< 0.001) and overweight (18.96 ± 18.75 ng/ml,P= 0.471) individuals were significantly higher than those in normal weight individuals (14.30 ± 9.37 ng/ml). Linear regression analysis revealed that the FABP1 levels were positively correlated with BMI (R2= 0.201, ***P< 0.001), ALT (R2= 0.324, ***P< 0.001), AST (R2= 0.387, ***P< 0.001), m-AST (R2= 0.160, ***P< 0.001),γ-GT (R2= 0.106, ***P< 0.001), DBil (R2= 0.078, ***P< 0.001), UA (R2= 0.111, ***P< 0.001), FBG (R2= 0.066, ***P< 0.001), LDL (R2= 0.042, **P= 0.005), and were negatively correlated with HDL (R2= 0.051, **P= 0.002). After adjusting for age, sex, ALT, AST, TC, TG, HDL, LDL, FBG, and UA, FABP1 was independently correlated with BMI (*P< 0.05). With decreasing BMI after LSG, the FABP1 levels (29.46 ± 21.19 ng/ml,P= 0.463,P= 0.06, *P< 0.05) also decreased at 3 (23.00 ± 22.77 ng/ml), 6 (14.41 ± 15.48 ng/ml), and 12 months (11.55 ± 3.27 ng/ml).ConclusionSerum FABP1 levels are closely correlated with obesity and many metabolic factors, and we found that with the decrease in BMI after LSG, the FABP1 levels also progressively decreased postoperatively.Trial RegistrationClinicalTrials.gov Identifier: ChiCTR-OCS-12002381