Preparation of particulate polymeric therapeutics for medical applications.
Preparation of particulate polymeric therapeutics for medical applications.
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DOI：
10.1002/smtd.201700147
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发表时间：
2017-09
期刊：
影响因子：
12.4
通讯作者：
Zhu Jia;Ronnie H. Fang;Liangfang Zhang
中科院分区：
文献类型：
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作者：
Zhu Jia;Ronnie H. Fang;Liangfang Zhang
在过去的几十年里，由聚合物材料制成的颗粒治疗剂变得越来越流行。一般来说，聚合物系统易于合成，并且具有可调参数，使其具有在临床上广泛使用的巨大潜力。它们有许多不同的形式，包括纳米颗粒、微粒和胶体凝胶。在这篇综述中，我们讨论了目前每种类型的平台的制备方法，以及一些代表性的应用。为了实现增强的性能，还提到了脂质涂层和用于引入额外功能的其他表面改性技术。我们希望，通过概述其制备的各种方法和技术，将有可能为这些聚合物平台的实用性提供见解，并进一步鼓励其在生物医学应用中的发展。
Particulate therapeutics fabricated from polymeric materials have become increasingly popular over the past several decades. Generally, polymeric systems are easy to synthesize and have tunable parameters, giving them significant potential for wide use in the clinic. They come in many different forms, including as nanoparticles, microparticles, and colloidal gels. In this review, we discuss the current preparation methods for each type of platform, as well as some representative applications. To achieve enhanced performance, lipid coatings and other surface modification techniques for introducing additional functionality are also mentioned. We hope that, by outlining the various methods and techniques for their preparation, it will be possible to provide insights into the utility of these polymeric platforms and further encourage their development for biomedical applications.