HORMONAL DYNAMICS AT MIDCYCLE - A REEVALUATION
HORMONAL DYNAMICS AT MIDCYCLE - A REEVALUATION
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DOI：
10.1210/jcem-57-4-792
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发表时间：
1983-01-01
影响因子：
5.8
通讯作者：
YEN, SSC
中科院分区：
文献类型：
--
作者：
HOFF, JD;QUIGLEY, ME;YEN, SSC
动态卵巢和垂体激素的变化在周期中期期间进行了评估。激素水平的变化，确定在2小时的时间间隔，连续5天，在周期的排卵期在5名妇女。在峰期开始前50小时内，雌二醇（E2）、孕酮（P4）和LH [促黄体激素]的增量率相似，倍增时间为57-61小时。LH和FSH激增突然发生（LH在2小时内加倍）。它们在时间上与E2峰值水平的达到相关，并在P4快速上升开始后12小时发生。浪涌的平均持续时间为48小时，快速上升的肢体（倍增时间，5.2小时）持续14小时，伴随着E2的快速下降和P4的持续上升。激增之后是持续14小时的促性腺激素水平的峰值平台和P4的瞬时水平。较长的下降肢（半衰期，9.6小时），持续20小时，与第二次快速上升的P4，开始36小时后，浪涌发作或终止前12小时。通过使用LH峰的发作作为参考点，数据提供了一个相对精确的图片的激素变化之前的促性腺激素峰的发作和多相P4上升和垂体卵巢功能之间的时间关系。
The dynamics of ovarian and pituitary hormone changes during the midcycle period were evaluated. Changes in hormone levels were determined at 2 h intervals for 5 consecutive days during the periovulatory phase of the cycle in 5 women. During the 50 h preceding the onset of the surge, the rates of increments for estradiol (E2), progesterone (P4), and LH [lutropin] were similar, with doubling times of 57-61 h. The onset of LH and FSH surges occurred abruptly (LH doubled within 2 h). They were temporally associated with the attainment of peak E2 levels and occurred 12 h after the initiation of a rapid rise of P4. The mean duration of the surge was 48 h, with a rapidly ascending limb (doubling time, 5.2 h) lasting 14 h accompanied by a rapid decline of E2 and a continued rise of P4. The surge was followed by a peak plateau of gonadotropin levels lasting for 14 h and a transient leveling of P4. The longer descending limb (half-time, 9.6 h), lasting for 20 h, was associated with a 2nd rapid rise of P4, beginning 36 h after surge onset or 12 h before termination of the surge. By using the onset of the LH surge as a reference point, the data provide a relatively precise picture of the hormonal changes preceding the onset of the gonadotropin surge and the temporal relationship between the multiphase P4 rise and pituitary-ovarian function.