Regulation of trophoblast invasion -: A workshop report
Regulation of trophoblast invasion -: A workshop report
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DOI：
10.1016/j.placenta.2007.11.008
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发表时间：
2008-03-01
期刊：
影响因子：
3.8
通讯作者：
Armant, D. R.
中科院分区：
文献类型：
--
作者：
Knoefler, M.;Simmons, D. G.;Armant, D. R.
胎盘发育过程中滋养层细胞的侵入有助于在母体和胎儿循环系统之间建立有效的生理交换。滋养层干细胞分化成多种亚型，包括一些高度侵袭性的亚型。蜕膜、子宫自然杀伤细胞和血管平滑肌向滋养层细胞发出信号，可调节绒毛外滋养层细胞的分化。重要的问题仍然是这些细胞的相互作用如何促进滋养层细胞的入侵和参与的信号通路。新的和建立的生物模型正在被用来实验研究这些相互作用和潜在的分子机制。(C)2007年由IFPA和Elsevier Ltd.出版
Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms. (C) 2007 Published by IFPA and Elsevier Ltd.