Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease.
Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease.
复制标题
骨髓移植后早期肠道微生物群多样性低会增加慢性移植物抗宿主病的风险。
DOI：
10.1038/s41409-021-01249-2
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Shibayam
中科院分区：
文献类型：
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作者：
Konishi T;Kusakabe S;Hino A;Inamoto K;Yoshifuji K;Kiridoshi Y;Takeshita K;Sasajima S;Toya T;Igarashi A;Najima Y;Kobayashi T;Doki N;Motooka D;Nakamura S;Suyama M;Suda W;Shiota A;Atarashi K;Hattori M;Honda K;Yokota T;Ohashi K;Shibayam
虽然异基因造血干细胞移植（allo-HSCT）是一种潜在的治疗血液病患者，移植相关的并发症有时成为严重的问题。其中，慢性移植物抗宿主病（cGVHD）是最重要的晚期并发症之一，可降低移植后患者的生活质量，甚至威胁患者的生命[1]。越来越多的证据表明，肠道菌群及其代谢产物与移植结局密切相关。虽然在急性GVHD（aGVHD）的发病率中观察到了下肠道微生物群的多样性[2]，但很少有研究报告cGVHD中存在类似的关系[3]。因此，我们回顾
Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for patients with hematological diseases, transplant-related complications sometimes become seriously problematic. Of these, chronic graft-versus-host disease (cGVHD) is one of the most important late-phase complications that reduce the quality of life and may even threaten the lives of posttransplant patients [1].An increasing body of evidence indicates that gut microbiota and their metabolites are closely associated with transplant outcomes. Although lower gut microbiota diversity has been observed in the incidence of acute GVHD (aGVHD)[2], few studies have reported a similar relationship in cGVHD [3]. Thus, we retrospectively