Biosynthesis of the polysialic acid capsule in Escherichia coli K1.
Biosynthesis of the polysialic acid capsule in Escherichia coli K1.
复制标题
大肠杆菌 K1 中聚唾液酸胶囊的生物合成。
DOI：
10.1007/bf01569991
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Cieslewicz,M
中科院分区：
文献类型：
--
作者：
Vimr,E;Steenbergen,S;Cieslewicz,M
The extracellular polysaccharides elaborated by most or all bacterial species function in cell-to-cell and cell-substratum adhesion, cell signaling, and avoidance or inhibition of noxious agents in animal hosts or free-living environments. Recent advances in our understanding of exopolysaccharide synthesis have been facilitated by comparative approaches in both plant and animal pathogens, as well as in microorganisms of industrial importance. One of the best understood of these systems is thekpslocus for polysialic acid synthesis inEscherichia coliK1. The genes for sialic acid synthesis, activation, polymerization and translocation have been identified and assigned at least tentative functions in the synthetic and export pathways. Initial studies ofkpsthermoregulation suggest that genetic control mechanisms will be involved which are distinct from those already described for several other exopolysaccharides. Information about the common as well as unique features of polysialic acid biosynthesis will increase our knowledge of microbial cell surfaces which in turn may suggest novel targets for therapeutic or industrial interventions.
