A Renewed Focus on GDF11 Level Fluctuation in Human Serum in Relation to Physical Examination Indicators
A Renewed Focus on GDF11 Level Fluctuation in Human Serum in Relation to Physical Examination Indicators
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重新关注人血清中GDF11水平波动与体检指标的关系
DOI：
10.1093/gerona/glz129
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发表时间：
2020-06-01
影响因子：
5.1
通讯作者：
Li, Quanyang
中科院分区：
文献类型：
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作者：
Liang, Xiaolin;Dou, Xiaowei;Li, Quanyang
生长与分化因子11 （GDF11）是转化生长因子β超家族的一员。先前的研究表明，GDF11随着年龄的增长而减少，具有抗衰老作用；然而，这样的报道是有争议的。我们选择了152名受试者，涵盖了很大的年龄范围（2小时至75岁）来测量血清GDF11。测定22项血液学指标和13项生化指标。Pearson分析发现GDF11与年龄（p = 0.00000, r = 0.4898）以及血清肌酐、尿酸、甘油三酯、红细胞计数、血红蛋白、红细胞压积和血小板体积分布宽度之间存在显著相关性。GDF11与天冬氨酸转氨酶、白细胞计数、血小板计数、淋巴细胞计数、单核细胞计数、平均血小板体积、血小板电积呈负相关。有趣的是，我们发现GDF11在20-30岁的人群中增加，在30-50岁的人群中保持稳定，在50岁以上的人群中增加。结果表明，GDF11在整个生命周期中发挥着不同的作用。目前的实际证据支持GDF11有助于促进衰老。
Growth and differentiation factor 11 (GDF11) is a member of the transforming growth factor beta superfamily. Previous studies have shown that GDF11 decreases with age and has antiaging effects; however, such reports are controversial. We choose 152 subjects covering a large age range (2 hours to 75 years) to measure serum GDF11. Twenty-two hematological variables and 13 biochemical values were measured. Pearson's analysis found a significant correlation between GDF11 and age (p = .0000, r = .4898), as well as serum creatinine, uric acid, triglycerides, red blood cell count, hemoglobin, hematocrit, and platelet volume distribution width. GDF11 negatively correlated with aspartate transaminase, white blood cell count, platelet count, lymphocyte count, monocyte count, mean platelet volume, and plateletcrit. Interestingly, we found GDF11 increases in people aged 20-30 years, holds steady in people aged 30-50 years, and increases in people older than 50 years. The results suggest that GDF11 serves different roles along the life span. The current actual evidence supports that GDF11 is helpful to promote aging.