Tobacco Exposure as Determined by Serum Cotinine and Subclinical Myocardial Injury in Individuals Free from Cardiovascular Disease
Tobacco Exposure as Determined by Serum Cotinine and Subclinical Myocardial Injury in Individuals Free from Cardiovascular Disease
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DOI：
10.1016/j.amjcard.2017.06.050
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发表时间：
2017-10-01
影响因子：
2.8
通讯作者：
Soliman, Elsayed Z.
中科院分区：
文献类型：
--
作者：
Ali, Muhammad;Li, Yabing;Soliman, Elsayed Z.
在美国，烟草暴露（包括二手烟）是导致过早死亡的主要可预防原因。血清可替宁是烟草暴露的高度敏感和特异性生物标志物，是比自我报告的吸烟状态更准确的烟草暴露测量。尽管烟草暴露对心血管疾病（CVD）危险因素（例如，动脉粥样硬化）或硬CVD结果（例如，心肌梗死）是公认的，它对中间结果，如亚临床心肌损伤（SMI），特别是在非吸烟者，的影响尚不清楚。因此，我们在第三次全国健康和营养检查调查中登记的6，264名无CVD的吸烟者和非吸烟者中检查了SMI的风险，SMI定义为12导联心电图上的心肌梗死/损伤评分点，血清可替宁水平异常（>15 ng/ml）。SMI在血清可替宁水平异常的患者中比在血清可替宁水平正常的患者中更常见（分别为25.9%和19.6%; p
Tobacco exposure including second-hand smoke is the leading preventable cause of premature death in the United States. Serum cotinine, a highly sensitive and specific biomarker for tobacco exposure, is a more accurate measure of tobacco exposure than self-reported smoking status. Although the harmful effect of tobacco exposure on cardiovascular disease (CVD) risk factors (e.g., atherosclerosis) or hard CVD outcomes (e.g., myocardial infarction) is well established, its effect on intermediate outcomes such as subclinical myocardial injury (SMI), especially in nonsmokers, is not clear. Therefore, we examined the risk of SMI, defined as a Cardiac Infarction/Injury Score of points on the 12-lead electrocardiogram with abnormal serum cotinine levels (>15 ng/ml) in 6,264 smokers and nonsmokers who were free from CVD enrolled in the Third National Health and Nutrition Examination Survey. SMI was more common in those with abnormal compared with normal serum cotinine levels (25.9% vs 19.6 %, respectively; p