Proton T1 and T2 relaxivities of serum proteins
Proton T1 and T2 relaxivities of serum proteins
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DOI：
10.1016/j.mri.2004.02.001
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发表时间：
2004-06-01
影响因子：
2.5
通讯作者：
Batun, MS
中科院分区：
文献类型：
--
作者：
Yilmaz, A;Ulak, FS;Batun, MS
在本研究中，T-1和T-2的幻影含有血清组与不同量的蛋白质，血清样品与一定量的蛋白质，血清稀释的蒸馏水，血清与铁处理进行了测量。此外，还测定了含有正常血清、稀释血清和白蛋白掺杂血清的模型的T-1和T-2。将舒张速率与蛋白质浓度作图。关系的斜率被视为弛豫率。蛋白质的T-1弛豫率范围为0.035 - 0.080 s（-1）（g/dl）（-1），而T-2弛豫率范围为0.24 - 0.68 s（-1）（g/dl）（-1）。转铁蛋白铁的T-1和T-2弛豫系数分别为2.40和2.60 mM（-1）s（-1）。抗磁性蛋白质和转铁蛋白铁的血清的弛豫速率的贡献也被计算为每个稀释的血清，正常和白蛋白掺杂的血清。使用贡献和平均TP弛豫率（通过使用单个弛豫率和TP中蛋白质组分的比率计算）进行TP计算。计算的TP与用自动分析仪测得的TP一致，平均TP弛豫率与稀释实验测得的TP弛豫率一致，表明弛豫率数据是可靠的。结果表明，个别蛋白松弛解释血清TP组成的影响T-1和T-2弛豫时间。(C)2004爱思唯尔公司All rights reserved.
In the present study, T-1 and T-2 of phantoms containing serum sets with varying amounts of proteins, serum samples with certain amounts of proteins, serum diluted by distilled water, and serum treated with iron were measured. In addition, T-1 and T-2 of phantoms containing normal serum, diluted serum, and albumin-doped serum were also measured. Relaxation rates were plotted versus protein concentrations. The slope of relation was taken as relaxivity. The T-1 relaxivities of proteins were ranged from 0.035 to 0.080 s(-1)(g/dl)(-1), whereas T-2 relaxivities were ranged from 0.24 to 0.68 s(-1)(g/dl)(-1). The T-1 and T-2 relaxivities of transferrin iron were 2.40 and 2.60 mM(-1)s(-1), respectively. The contributions of diamagnetic proteins and transferrin iron to the relaxation rate of serum were also calculated for each of diluted serum, normal and albumin-doped serum. The contributions and the average TP relaxivities(calculated by using individual relaxivities and the ratios of protein fractions in TP) were used for TP calculations. The agreement between the calculated TP and TP by autoanalyzer and also the agreement between average TP relaxivities and the TP relaxivities determined from dilution experiments show that the data of relaxivities are reliable. The results suggest that individual protein relaxivities explain the influence of serum TP composition on T-1 and T-2 relaxation times. (C) 2004 Elsevier Inc. All rights reserved.