A systematic review of the factors influencing microbial colonization of the preterm infant gut.
A systematic review of the factors influencing microbial colonization of the preterm infant gut.
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DOI：
10.1080/19490976.2021.1884514
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Donovan SM
中科院分区：
文献类型：
--
作者：
Aguilar-Lopez M;Dinsmoor AM;Ho TTB;Donovan SM
早产加上早产儿（PT）的必要临床管理引入了多种可能干扰微生物定植的因素。本研究旨在综述与PT婴儿肠道菌群相关的围产期、生理、药理、饮食和环境因素。通过检索多个数据库，共检索到587篇文章。在删除重复和不符合纳入标准的文章后，60项研究被纳入综述。对该文献的审查显示，证据集中在出生后年龄、分娩方式、抗生素使用和母乳消耗对PT婴儿肠道微生物群组成的影响上。较少的证据表明与种族，性别，使用不同的强化剂，常量营养素和其他药物有关。未来需要进行具有丰富元数据的研究，以进一步探索PT代谢组对这一高危人群中微生物群发育的影响。
Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.