A novel test of conditioned inhibition correlates with personality measures of schizotypy and reward sensitivity
A novel test of conditioned inhibition correlates with personality measures of schizotypy and reward sensitivity
复制标题
DOI：
10.1016/j.bbr.2005.11.021
复制
发表时间：
2006-04-03
影响因子：
2.7
通讯作者：
Cassaday, HJ
中科院分区：
文献类型：
--
作者：
Migo, EA;Corbett, K;Cassaday, HJ
当一个信号(条件刺激，CS)的意义被另一个信号(条件抑制，CI)限定时，条件抑制就被证明。虽然单独提供的CS可以可靠地预测结果(无条件刺激，US)，但当与CI一起提供时，否则预期的US将不会发生。条件性抑制在动物研究中早已确立，但在建立适用于人类研究的可靠程序方面一直存在困难。这类程序对于研究认知抑制机制已知有缺陷的障碍是必要的，例如精神分裂症。在健康参与者中，显示条件性抑制倾向的个体差异应该与认知抑制的个性措施有关。在本研究中，这是使用自动测试程序进行测量的。其中视觉刺激预测视觉结果US的发生或不发生，以及BIS/BAS和分裂类型等级。条件性抑制在两个不同的测试变种中是可靠的，其中US的不出现被不同地指定，并通过总和测试得到确认。CI水平与BAS奖赏反应呈正相关，但与其他任何BIS/BAS量表均无显著相关性。相反，CI水平与分裂类型呈负相关。我们建议，这种新的条件抑制任务现在应该被应用于研究一系列在功能障碍的抑制过程中有一定基础的疾病，如精神分裂症。(C)2005 Elsevier B.V.保留所有权利。
Conditioned inhibition is demonstrated when the meaning of one signal (conditioned stimulus, CS) is qualified by another (conditioned inhibitor, CI). Whilst the CS presented alone reliably predicts the outcome (unconditioned stimulus, US), when presented in conjunction with the CI the otherwise expected US will not occur. Conditioned inhibition has long been established in animal research but there have been difficulties in establishing reliable procedures suitable for use in human research. Such procedures are necessary to investigate disorders in which cognitive inhibitory mechanisms are known to be deficient, e.g., schizophrenia. In healthy participants, individual differences in the tendency to show conditioned inhibition should be related to personality measures of cognitive inhibition. In the present study, this was measured using an automated test procedure. in which visual stimuli predict the occurrence or non-occurrence of a visual outcome US, and BIS/BAS and schizotypy scales. Conditioned inhibition was reliable across two alternative test variants, in which the non-occurrence of the US was specified differently, and was confirmed by summation tests. The level of CI shown was positively associated with BAS Reward Responsiveness but did not correlate significantly with any of the other BIS/BAS scales. Conversely, the level of CI shown was negatively associated with schizotypy. We suggest that this novel conditioned inhibition task should now be applied to investigate a range of disorders that have some basis in dysfunctional inhibitory processes, such as schizophrenia. (c) 2005 Elsevier B.V. All rights reserved.