Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota
Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota
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DOI：
10.1016/j.preghy.2021.01.002
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发表时间：
2021-01-30
影响因子：
2.2
通讯作者：
Nitert, Marloes Dekker
中科院分区：
文献类型：
--
作者：
Altemani, Faisal;Barrett, Helen L.;Nitert, Marloes Dekker
子痫前期是妊娠期特有的疾病，其特征是高血压和多个器官功能障碍，与母体和胎儿并发症有关。人类肠道微生物群与健康和疾病有关，包括高血压。肠道微生物群组成的改变可以改变细菌释放的短链脂肪酸谱，并导致高血压和代谢综合征。目前尚不清楚在发展为晚发型先兆子痫的女性中肠道微生物群的组成是否发生改变。在这项研究中，我们通过对从SPRING队列中的213名孕妇获得的粪便样本进行16S rRNA基因扩增子测序（益生菌在妊娠糖尿病中的研究），研究了发生晚发型（>34周妊娠）先兆子痫（DPE）的妇女在妊娠28周时肠道微生物群的组成。实时定量PCR用于评估丁酸盐产生基因的密度。肠道微生物群的组成进行了比较，妇女与没有DPE。产丁酸粪球菌属的丰度在DPE中显著降低。粪球菌属的减少与编码细菌丁酸盐形成的末端步骤（but和布克）的基因的丰度显著正相关。与对照组相比，患有DPE的妇女在症状发展之前血清丁酸水平也显著降低。这项研究表明，丁酸生产细菌和粪球菌的丰度减少。特别是可能导致孕妇发生先兆子痫的风险增加。
Preeclampsia is a pregnancy-specific disorder characterized by hypertension and dysfunction of several organs, that is associated with maternal and fetal complications. The human gut microbiota is related to health and disease including hypertension. Alterations in gut microbiota composition can change the short-chain fatty acid profile released by the bacteria and contribute to hypertension and metabolic syndrome. It is unclear if the composition of the gut microbiota is altered in women who develop late-onset preeclampsia. In this study, we investigated the composition of the gut microbiota at 28 weeks gestation in women who developed late-onset (>34 weeks gestation) preeclampsia (DPE) by 16S rRNA gene amplicon sequencing of fecal samples obtained from 213 pregnant women in the SPRING cohort (Study of Probiotics IN Gestational diabetes). Quantitative realtime PCR was used to assess the density of butyrate-producing genes. Gut microbiota composition was compared between women with and without DPE. The abundance of the butyrate-producing Coprococcus genus significantly decreased in DPE. Abundance of Coprococcus is significantly and positively correlated with the abundance of genes encoding the terminal step in bacterial butyrate formation (but and buk). Women with DPE also had significantly reduced levels of serum butyrate prior to the development of symptoms than controls. This study suggests that a reduction in the abundance of butyrate-producing bacteria, and Coprococcus spp. in particular, may contribute to an increased risk of developing preeclampsia in pregnant women.