Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging
Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging
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DOI：
10.1016/j.neurobiolaging.2005.09.014
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Messier, C
中科院分区：
文献类型：
--
作者：
Messier, C
2型糖尿病在大多数西方国家越来越普遍，现在发生在年轻人身上。糖尿病有多种病理学表现，大多数是全身性的。然而，越来越多的研究也表明，糖尿病与老年人认知过程受损有关，并加速痴呆症的进展。最常见的认知缺陷是处理速度和言语记忆的下降;随着年龄的增长，这些可能会扩展到认知的其他方面。糖尿病和认知能力下降之间的联系被抑郁症、高血压以及心脑血管疾病所掩盖，所有这些疾病都不同程度地发生在糖尿病患者中。一些研究表明，通过抗糖尿病治疗控制血糖可能有助于预防糖尿病患者在70岁之前的认知能力下降。在这个年龄之后，糖尿病似乎会产生更快的认知能力下降，并可能增加与血管性痴呆或阿尔茨海默病相关的病理变化的发生。(c)2005年爱思唯尔公司All rights reserved.
Type 2 diabetes is becoming increasingly common in most Westemized countries and it now occurs at a younger age. There are pathologies associated with diabetes, mostly systemic ones. However, a growing number of studies is also showing that diabetes is associated with impaired cognitive processes in older adults and hasten the progression to dementia. The most common cognitive deficits are decreases in processing speed and verbal memory; these may extend to other aspects of cognition with increasing age. The link between diabetes and cognitive decline is obscured by depression, hypertension, as well as cardio- and cerebrovascular diseases, all of which occur to varying degrees in diabetic patients. A few studies indicate that controlling blood glucose with anti-diabetic treatments may help prevent the cognitive decline in diabetic patients before they are 70 years old. After that age, diabetes appears to produce faster cognitive decline and may increase the occurrence of pathological changes associated with vascular dementia or Alzheimer's disease. (c) 2005 Elsevier Inc. All rights reserved.