Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
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来自非洲和美洲伯基特型和非伯基特型未分化淋巴瘤的细胞系分泌的免疫球蛋白。
DOI：
10.4049/jimmunol.129.3.1336
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发表时间：
1982
影响因子：
4.4
通讯作者：
R. Parsons
中科院分区：
文献类型：
--
作者：
D. Benjamin;I. Magrath;R. Maguire;C. Janus;H. Todd;R. Parsons
作为伯基特型和非伯基特型未分化淋巴瘤的细胞起源的调查的一部分，我们已经检查了免疫球蛋白分泌的细胞系和活检样品从这些肿瘤，并与其他淋巴母细胞样细胞系进行了比较。大多数美国淋巴瘤细胞系和一小部分非洲淋巴瘤细胞系分泌单克隆IgM。无其他IG类分泌。还发现肿瘤样品的IG分泌仅为IgM。分泌的IgM呈多聚体，与J链结合。观察到大多数肿瘤细胞系分泌游离轻链。通过免疫测定的定量表明，美国淋巴瘤细胞系分泌的IgM显著多于非洲淋巴瘤细胞系。我们提出淋巴瘤细胞代表B细胞分化的早期阶段，在此期间发生抗原非依赖性分泌。
As part of an investigation of the cellular origins of undifferentiated lymphomas of the Burkitt's and non-Burkitt's types, we have examined immunoglobulin secretion by cell lines and biopsy samples from these tumors and have compared it with other lymphoblastoid cell lines. The majority of American lymphoma cell lines and a smaller fraction of African lymphoma cell lines secreted monoclonal IgM. No other Ig classes were secreted. Ig secretion by the tumor samples was also found to be exclusively IgM. The secreted IgM was polymeric and associated with J chain. Secretion of free light chain by most of the tumor cell lines was observed. Quantitation by immunoassay demonstrated that the American lymphoma cell lines secreted significantly more IgM than the African lymphoma cell lines. We have proposed that the lymphoma cells represent an early stage of B cell differentiation, during which antigen-independent secretion occurs.