Dental Lamina as Source of Odontogenic Stem Cells: Evolutionary Origins and Developmental Control of Tooth Generation in Gnathostomes
Dental Lamina as Source of Odontogenic Stem Cells: Evolutionary Origins and Developmental Control of Tooth Generation in Gnathostomes
复制标题
DOI：
10.1002/jez.b.21272
复制
发表时间：
2009-06-15
影响因子：
2.2
通讯作者：
Mitsiadis, Thimios A.
中科院分区：
文献类型：
--
作者：
Smith, Moya M.;Fraser, Gareth J.;Mitsiadis, Thimios A.
本研究认为干细胞的牙源性能力在生物牙齿更新的广泛背景下，颌牙列和口腔上皮细胞的衍生。牙板的发育位点和细胞动力学的位置是牙源性上皮干细胞的可能来源的参数，但系统发育史尚不清楚。本研究的最终目的是了解基颌脊椎动物牙齿连续更新过程中干细胞起源的系统发育基础。了解干细胞在牙列发育中的起源和位置的关键是将干细胞局部隔离用于程序性牙齿更新。我们建议不仅在每个齿状领域的初始模式的差异，但随后在每个家庭内的牙齿更新的局部控制。特化的牙源性上皮（牙源性带）的作用被认为是干细胞驻留和分化的作用。这些调节时间，位置和形状在连续的牙齿生产。软骨鱼类的新组织学数据首先显示口腔上皮增厚（牙源带）。在此之后，所有的乳牙和后续牙齿仅从牙板深至口腔上皮生成。相反，硬骨鱼类的第一颗牙齿直接在牙源带内发育。此外，在前代牙胚（没有牙板）中的每个牙齿部位开始后续牙胚。我们认为，干细胞指定为每个牙齿家庭的设置和位于中间细胞之间的外部和内部的牙齿上皮。J. Exp. Zool.（Mol. Dev. Evol.）312 B：260-280，2009年。(c)2009威利-利斯公司
This study considers stem cells for odontogenic capability in biological tooth renewal in the broad context of gnathostome dentitions and the derivation of them from oral epithelium. The location of the developmental site and cell dynamics of the dental lamina are parameters of a possible source for odontogenic epithelial stem cells, but the phylogenetic history is not known. Understanding the phylogenetic basis for stem cell origins throughout continuous tooth renewal in basal jawed vertebrates is the ultimate objective of this study. The key to understanding the origin and location of stem cells in the development of the dentition is sequestration of stem cells locally for programmed tooth renewal. We suggest not only the initial pattern differences in each dentate field but local control subsequently for tooth renewal within each family. The role of the specialized odontogenic epithelium (odontogenic band) is considered as that in which the stem cells reside and become partitioned. These regulate time, position and shape in sequential tooth production. New histological data for chondrichthyan fish show first a thickening of the oral epithelium (odontogenic band). After this, all primary and successive teeth are only generated deep to the oral epithelium from a dental lamina. In contrast, in osteichthyan fish the first teeth develop directly within the odontogenic band. In addition, successors are initiated at each tooth site in the predecessor tooth germ (without a dental lamina). We suggest that stem cells specified for each tooth family are set up and located in intermediate cells between the outer and inner dental epithelia. J. Exp. Zool. (Mol. Dev. Evol.) 312B:260-280, 2009. (c) 2009 Wiley-Liss, Inc.