Modification of the adverse effects of cadmium exposure by steroid compounds in rodents: A review
Modification of the adverse effects of cadmium exposure by steroid compounds in rodents: A review
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类固醇化合物对啮齿类动物镉暴露不良影响的缓解：综述
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
M. Waalkes
中科院分区：
文献类型：
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作者：
H. Shimada;M. Takiguchi;M. Waalkes
镉是一种重要的金属毒素和环境污染物。在啮齿动物中，镉的急性和慢性毒性效应在几个组织中都很明显，包括肺、肝、肾、前列腺和睾丸。镉的毒性效应可以通过各种金属和非金属物质的预处理或同时处理来调节。本文综述了类固醇激素和类固醇拮抗剂对体内镉毒性的影响。类固醇对镉的毒性有多种影响，包括缓解和加剧这种金属的不利影响。已报道的可改变镉毒性的类固醇或类固醇拮抗剂包括睾酮、孕酮、环丙孕酮、雌二醇和己烯雌酚。一些类固醇，如地塞米松和皮质酮，是金属硫蛋白(MT)的诱导者，金属硫蛋白是一种镉结合蛋白，被认为在镉耐受中起重要作用。从这些报道中，已经提出了几种可能的机制来解释这种现象。
Cadmium is a very important m etal toxin and environmental pollutant. In rodents, the acute and chronic toxic effects of cadmium are pronounced in several tissues including the lung, liver, kidney, prostate, and testes. The toxic effects of cadmium can be modulated by pretreatments or concurrent treatments with various m etallic and nonmetallic substances. This review focuses on theeffects of steroid hormones and steroid antagonists on cadmium toxicity in vivo. Steroids can have a variety of effects on cadmium toxicity including both mitigation and exacerbation of the adverse effects of this metal. Steroids or steroid antagonists that have been reported to modify cadmium toxicity include testosterone, progesterone, cyproterone, estradiol, and stilbestrol. Some steroids, like dexam ethasone and corticosterone, are inducers of metallothionein (MT), a cadmium-binding protein thought to be im portant in cadm ium tolerance. From these reports several possible mechanisms have been proposed to explain the m odul...