ALTERATIONS IN TUMOR MICROVASCULATURE DURING HYPERTHERMIA
ALTERATIONS IN TUMOR MICROVASCULATURE DURING HYPERTHERMIA
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DOI：
10.1148/radiology.137.2.7433685
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发表时间：
1980-01-01
期刊：
影响因子：
19.7
通讯作者：
EDDY, HA
中科院分区：
文献类型：
--
作者：
EDDY, HA
肿瘤微血管系统对 41°C、43°C 加热的反应模式。和45度。在仓鼠颊囊室中生长的鳞状细胞癌中研究了 C 30 分钟。在每个温度下，直接反应是血管口径显着减小。随后返回至 41°C 的预热口径。 C、43℃时血管舒张。 C 和某些肿瘤在 45°C 时的血管舒张作用。 C. 41°C 时，血管基质发生最小的病理改变。 C，而在 43 度。 C、瘀点、瘀血、偶发血栓、部分内皮变性和持续充血是其特征。 45度。 C，发生压迫/闭塞、出血和瘀血/血栓形成，并且在每个肿瘤中，循环完全停止导致典型的凝固性坏死的图像。与直接细胞杀伤相比，肿瘤微血管系统的病理生理变化可能比直接细胞杀伤更能促进治愈。
The pattern of response of tumor microvasculature to heating at 41.degree., 43.degree. and 45.degree. C for 30 min was studied in squamous cell carcinoma grown in the cheek pouch chamber of the hamster. At each temperature, the immediate response was a prominent reduction in vascular caliber. This was followed by a return to preheating caliber at 41.degree. C, vasodilatation at 43.degree. C and vasodilatation in some tumors at 45.degree. C. Minimal pathologic alterations occurred in the vascular stroma at 41.degree. C, while at 43.degree. C, petechiae, stasis, occasional thromboses, some endothelial degeneration and persistent hyperemia were characteristic. At 45.degree. C, compression/occlusion, hemorrhage and stasis/thrombosis occurred, and in each tumor, complete shutdown of circulation led to a picture typical of coagulation necrosis. Pathophysiologic changes in the microvasculature of a tumor subjected to hyperthermia may account for a greater degree of cure than can be attributed to direct cell killing.