PTEN-Associated Complexes: An Overview.
PTEN-Associated Complexes: An Overview.
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发表时间：
2010
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通讯作者：
Sherly Mosessian;Hong Wu
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作者：
Sherly Mosessian;Hong Wu
PTEN是一种肿瘤抑制因子，以其作为脂质磷酸酶拮抗pi3激酶途径而闻名。最近的几项研究已经确定了在不同的亚细胞区室中与PTEN形成高分子量复合物的蛋白质。PTEN对早期胚胎发育、细胞增殖、细胞存活和干细胞功能至关重要。PTEN复杂组分的发现可能有助于我们了解其生物学功能。本文就PTEN的复杂成分、功能及其调控进行综述。
PTEN is a tumor suppressor best characterized for its role as a lipid phosphatase in antagonizing the PI3-kinase pathway. Several recent studies have identified proteins that form high molecular weight complexes with PTEN in different subcellular compartments. PTEN is critical for early embryonic development, cell proliferation, cell survival and stem cell function. The discovery of PTEN complex components may help our understanding of its biological functions. In this review, PTEN complex components, functions and their regulation will be discussed.