Age-related effects on circadian phase in the sleep of patients with depression and insomnia.
Age-related effects on circadian phase in the sleep of patients with depression and insomnia.
复制标题
年龄相关的抑郁症和失眠患者睡眠昼夜节律阶段的影响。
DOI：
10.1080/15402002.2013.855213
复制
发表时间：
2015
影响因子：
3.1
通讯作者：
McCall,WVaughn
中科院分区：
文献类型：
--
作者：
Xian,Hong;Gonzalez,Carlos;Deych,Elena;Farris,Suzan;Ding,Jimin;Shannon,William;McCall,WVaughn
我们使用日记和5个工作日的体动记录仪检查了60例抑郁症和失眠症患者（平均年龄41.5 [12.5]岁）是否存在与年龄相关的相位提前。采用功能数据分析法对腕动计进行分析。每个受试者的活动低点（深相）通过余弦函数与24小时周期时间拟合。线性回归分析显示，年龄的增加与早睡（p< 0.001）、睡眠时间的缩短（p< 0.05）和深潜期的提前（p< 0.001）有关。这些研究结果与之前的报告一致，即自我报告的良好睡眠者的睡眠行为具有年龄依赖性阶段性进展，并加强了这样一个前提，即老年失眠患者的个体化行为治疗可能需要比年轻失眠患者更早的就寝时间和更早的起床时间。此外，我们证明，老化的睡眠系统，至少反映在体动记录，发生早在第三个十年。
We examined whether an age-related phase advance was present in 60 patients with depression and insomnia (mean age 41.5 [12.5] years) using diaries and 5 weekdays of actigraphy. Actigraphy was analyzed with functional data analysis. The low point of activity (bathyphase) for each subject was fitted by cosine function with 24-hr cycle time. Linear regression analysis revealed that increasing age was associated with earlier bedtimes (p< 0.001), shorter sleep latencies (p< 0.05), and earlier bathyphase (p< 0.001). These findings are consistent with prior reports of age-dependent phase-advances in sleep behavior in self-reported good sleepers and reinforce the premise that individualized behavioral therapy of older persons with insomnia may require prescription of earlier bedtimes and earlier rise times than would be employed in younger persons with insomnia. Further, we demonstrate that aging of the sleep system, at least as reflected in actigraphy, occurs as early as the third decade.