A thermodynamical model for stress-fiber organization in contractile cells
A thermodynamical model for stress-fiber organization in contractile cells
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DOI：
10.1063/1.3673551
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发表时间：
2012-01-02
影响因子：
4
通讯作者：
Vernerey, Franck J.
中科院分区：
文献类型：
--
作者：
Foucard, Louis;Vernerey, Franck J.
细胞对外界刺激的机械适应性对其许多生物功能至关重要。因此，一个关键的问题是了解应力纤维的形成和组织，从中产生细胞的机械性能。通过占应力纤维的力学方面和粘弹性行为，我们在这里提出了一个热力学模型来预测应力纤维的形成和取向的收缩细胞进行恒定或循环拉伸和不同的基板刚度。我们的研究结果表明，应力纤维的粘弹性行为起着至关重要的作用，它们的形成和组织，并显示出良好的一致性与各种实验。(C)2012年美国物理学会。[doi：10.1063/1.3673551]
Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell's mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3673551]