Simulation of surface strain in tibiofemoral cartilage during walking for the prediction of collagen fiber orientation.
Simulation of surface strain in tibiofemoral cartilage during walking for the prediction of collagen fiber orientation.
复制标题
模拟步行过程中胫股软骨的表面应变，以预测胶原纤维方向。
DOI：
10.1080/21681163.2018.1442751
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Negrut,Dan
中科院分区：
文献类型：
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作者：
Rakhsha,Milad;Smith,ColinR;Recuero,Antonio;Brandon,ScottCE;Vignos,MichaelF;Thelen,DarrylG;Negrut,Dan
胫股关节软骨浅层中的胶原纤维呈明显的方向性，分割线显示。在这项研究中，我们引入了一个模拟框架来预测行走过程中软骨表面的载荷，以研究分割线方向是否与软骨表面的主应变方向相对应。该两步框架使用多体肌肉骨骼模型来预测胫股运动学，然后将其施加到可变形模型来预测表面应变。可变形模型使用绝对节点坐标公式(ANCF)壳单元来表示关节表面，并使用弹簧-阻尼器系统和内部压力来表示下面的软骨。进行了模拟，以预测由于内部压力、步行引起的载荷以及由于压力和步行两者的组合而产生的表面应变。在模拟行走中，股骨和胫骨软骨的峰值挠度略大于1 mm。首先，软骨表面的主应变值高达3%。当计入软骨内压引起的表面负荷时，时间平均的第一主应变与文献中的分割线图吻合得最好。这一结果表明，压力诱导的表面应变模式与出现的胶原纤维取向模式之间可能存在联系。
The collagen fibres in the superficial layer of tibiofemoral articular cartilage exhibit distinct patterns in orientation revealed by split lines. In this study, we introduce a simulation framework to predict cartilage surface loading during walking to investigate if split line orientations correspond with principal strain directions in the cartilage surface. The two-step framework uses a multibody musculoskeletal model to predict tibiofemoral kinematics which are then imposed on a deformable model to predict surface strains. The deformable model uses absolute nodal coordinate formulation (ANCF) shell elements to represent the articular surface and a system of spring-dampers and internal pressure to represent the underlying cartilage. Simulations were performed to predict surface strains due to internal pressure, loading induced by walking, and the combination of both loading due to pressure and walking. Peak femoral and tibial cartilage deflections were slightly greater than 1 mm during simulated walking. First principal strain magnitudes within the cartilage surface ranged up to 3%. Time-averaged first principal strains agreed best with split line maps from the literature when surface loading due to internal cartilage pressure was included. This result suggests there may be a connection between pressure-induced surface strain patterns and the collagen fibre orientation patterns that emerge.