Absolute photoacoustic thermometry in deep tissue.

Absolute photoacoustic thermometry in deep tissue.
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DOI:
10.1364/ol.38.005228
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发表时间:
2013-12-15
期刊:
影响因子:
3.6
通讯作者:
Wang LV
Wang LV
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Yao J;Ke H;Tai S;Zhou Y;Wang LV

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光声热成像技术是一种很有前途的深部组织测温技术。在这里,我们提出了一种绝对温度测量方法的基础上的双重温度依赖性的Grüneisen参数和声速的组织。通过在两个相邻温度下进行比率测量,我们可以消除与温度无关但难以在深部组织中校正的因素。为了验证我们的方法,在28 °C至46 °C的生物学相关范围内测量了嵌入鸡组织约9 mm深的血液填充管的绝对温度。温度测量精度约为0.6 °C。结果表明,我们的方法可以潜在地用于热疗过程中深部组织的绝对温度监测。
Photoacoustic (PA) thermography is a promising tool for temperature measurement in deep tissue. Here, we propose an absolute temperature measurement method based on the dual temperature dependences of the Grüneisen parameter and the speed of sound in tissue. By taking ratiometric measurements at two adjacent temperatures, we can eliminate the factors that are temperature irrelevant but difficult to correct for in deep tissue. To validate our method, absolute temperatures of blood-filled tubes embedded ~9 mm deep in chicken tissue were measured in a biologically relevant range from 28 °C to 46 °C. The temperature measurement accuracy was ~0.6 °C. The results suggest that our method can be potentially used for absolute temperature monitoring in deep tissue during thermotherapy.
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