Dexmedetomidine or medetomidine premedication before propofol desflurane anaesthesia in dogs
Dexmedetomidine or medetomidine premedication before propofol desflurane anaesthesia in dogs
复制标题
DOI：
10.1111/j.1365-2885.2006.00732.x
复制
发表时间：
2006-06-01
影响因子：
1.3
通讯作者：
Von der Burg, J
中科院分区：
文献类型：
--
作者：
Gómez-Villamandos, RJ;Palacios, C;Von der Burg, J
本研究的目的是评价右美托咪定作为丙泊酚-地氟烷麻醉前犬的术前用药，并将其与美托咪定进行比较。将6只健康犬麻醉。每只犬静脉内（i. v.）五种麻醉前方案：D1（右美托咪定，1 μ g/kg，静脉注射），D2（右美托咪定，2 μ g/kg，静脉注射），M1（美托咪定，1 μ g/kg，静脉注射），M2（美托咪定，2 μ g/kg，静脉注射），或M4（美托咪定，4 μ g/kg，静脉内）。用丙泊酚（2.3-3.3 mg/kg）诱导麻醉，并用地氟烷维持。研究了以下变量：心率（HR）、平均动脉压、动脉收缩压、动脉舒张压、呼吸频率（RR）、动脉血氧饱和度、潮气末CO2、维持麻醉所需的地氟烷潮气末浓度（EtDES）和潮气量。麻醉期间测定动脉血pH值（pHa）和动脉血气分压（PaO 2、PaCO 2）。还记录了拔管时间、胸骨卧位时间和站立时间。所有方案镇静期间HR和RR均显著降低。所有方案麻醉期间的呼吸系统变量在统计学上相似。EtDES在D1（8.1%）和D2（7.5%）之间以及所有剂量的美托咪定之间存在显著差异。D1和M2以及D2和M4方案的地氟烷要求相似。在恢复时间方面未观察到统计学差异。右美托咪定、丙泊酚和地氟烷的组合似乎可有效诱导和维持健康犬的全身麻醉。
The objective of this study was to evaluate dexmedetomidine as a premedicant in dogs prior to propofol-desflurane anaesthesia, and to compare it with medetomidine. Six healthy dogs were anaesthetized. Each dog received intravenously (i.v.) five preanaesthetic protocols: D1 (dexmedetomidine, 1 mu g/kg, i.v.), D2 (dexmedetomidine, 2 mu g/kg, i.v.), M1 (medetomidine, 1 mu g/kg, i.v.), M2 (medetomidine, 2 mu g/kg, i.v.), or M4 (medetomidine, 4 mu g/kg, i.v.). Anaesthesia was induced with propofol (2.3-3.3 mg/kg) and maintained with desflurane. The following variables were studied: heart rate (HR), mean arterial pressure, systolic arterial pressure, diastolic arterial pressure, respiratory rate (RR), arterial oxygen saturation, end-tidal CO2, end-tidal concentration of desflurane (EtDES) required for maintenance of anaesthesia and tidal volume. Arterial blood pH (pHa) and arterial blood gas tensions (PaO2, PaCO2) were measured during anaesthesia. Time to extubation, time to sternal recumbency and time to standing were also recorded. HR and RR decreased significantly during sedation in all protocols. Cardiorespiratory variables during anaesthesia were statistically similar for all protocols. EtDES was significantly different between D1 (8.1%) and D2 (7.5%), and between all doses of medetomidine. Desflurane requirements were similar for D1 and M2, and for D2 and M4 protocols. No statistical differences were observed in recovery times. The combination of dexmedetomidine, propofol and desflurane appears to be effective for induction and maintenance of general anaesthesia in healthy dogs.