Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain-Optical Coherence Tomography Study
Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain-Optical Coherence Tomography Study
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DOI：
10.1167/iovs.09-4189
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发表时间：
2010-08-01
影响因子：
4.4
通讯作者：
Kim, Sung Soo
中科院分区：
文献类型：
--
作者：
Song, Won Kyung;Lee, Sung Chul;Kim, Sung Soo
目的。利用光谱域光学相干断层扫描（SD-OCT）评估黄斑视网膜厚度和体积与年龄、性别和屈光不正/轴长之间的关系。在2008年7月至2009年1月期间，对矫正视力在20/30以上的198名连续眼正常受试者（男104名，女94名）随机选取一只眼进行横断面研究。进行完整的眼科检查，激光干涉仪测量眼轴长度，SD-OCT扫描黄斑立方体512 × 128。平均年龄为55.6 +/- 16.4岁（范围17-83），平均屈光不正为-2.17 +/- 4.82（范围-23.50-3.75），平均眼轴长度为24.73 +/- 1.98 mm（范围21.52-32.51）。女性受试者的中心子野厚度、平均黄斑内厚度和整体黄斑体积均显著低于女性受试者（偏相关：P = 0.009、P = 0.027和P = 0.042）。随着年龄的增长，黄斑内侧平均厚度、外侧平均厚度、整体平均厚度和黄斑体积均显著降低（偏相关分别为P = 0.002、P = 0.002、P = 0.002和P = 0.000）。偏相关分析对屈光不全无显著影响。轴向长度与黄斑外侧平均厚度、黄斑整体平均厚度和黄斑体积呈负相关（部分相关：P = 0.006、P = 0.044和P = 0.003）。在正常受试者中，SD-OCT显示视网膜厚度与年龄、性别和轴向长度有关，存在区域差异。（中国眼科杂志，2010;51:3913-3918）DOI: 10.1167/iovs.09-4189
PURPOSE. To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT).METHODS. One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 x 128 scan by SD-OCT were performed.RESULTS. The mean age was 55.6 +/- 16.4 years (range, 17-83), average refractive error was -2.17 +/- 4.82 (range, -23.50-3.75), and average axial length was 24.73 +/- 1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively).CONCLUSIONS. In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations. (Invest Ophthalmol Vis Sci. 2010; 51: 3913-3918) DOI: 10.1167/iovs.09-4189