The influence of APOE status on episodic and semantic memory:: Data from a population-based study
The influence of APOE status on episodic and semantic memory:: Data from a population-based study
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DOI：
10.1037/0894-4105.20.6.645
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发表时间：
2006-11-01
期刊：
影响因子：
2.4
通讯作者：
Van Broeckhoven, Christine
中科院分区：
文献类型：
--
作者：
Nilsson, Lars-Goran;Adolfsson, Rolf;Van Broeckhoven, Christine
在一项前瞻性队列研究中，作者证明 70 岁及以上的参与者在评估情景回忆的任务中存在更明显的 epsilon 4 相关缺陷。载脂蛋白 E (APOE) 和年龄在情景记忆任务中相互作用，而在语义记忆任务中，APOE 和测试波之间存在相互作用。中年和青年参与者之间的ε4杂合子在回忆任务中比该等位基因的非携带者表现得更高。研究发现剂量效应使得2ε4等位基因的携带者在获取和回忆情景信息方面比1ε4等位基因的携带者更严重地失败，而1ε4等位基因的携带者又比非ε4等位基因的携带者失败更多。对老年 epsilon 4 携带者观察到的结果表明，当执行任务要求很高时，这些人会遇到特别困难。有几个因素（例如，海马体积较小、神经修复机制效率较低）可能解释了这些发现。根据获得的数据，作者认为，对特定基因对认知的影响的分析应该伴随着对特定水平表现的评估，并适当注意个人的年龄。
In a prospective cohort study, the authors demonstrated a more pronounced epsilon 4-related deficit for participants 70 years of age and older in tasks assessing episodic recall. Apolipoprotein E (APOE) and age interacted for episodic memory tasks, whereas the interaction for semantic memory tasks was between APOE and test wave. Heterozygotes of epsilon 4 between middle-age and young-old participants performed at a higher level than noncarriers of this allele in recall tasks. A dose effect was found such that carriers of 2 epsilon 4 alleles failed more profoundly in acquiring and recollecting episodic information than carriers of 1 epsilon 4 allele, who in turn failed more than carriers of non-epsilon 4 alleles. The pattern of findings observed for older epsilon 4 carriers suggests that these individuals have particular difficulty when the executive task demands are high. Several factors (e.g., smaller hippocampal volumes, less effective neural repair mechanisms) may account for these findings. On the basis of the data obtained, the authors argue that analyses of the effect of specific genes in cognition should be accompanied by assessment of performance at a specific level, with due attention to the individual's age.