'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle.
'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle.
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“Disc-o-Fever”：了解贾第虫的 Groovy 微管细胞器。
DOI：
10.1016/j.tcb.2017.10.007
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发表时间：
2018
影响因子：
19
通讯作者：
Dawson,ScottC
中科院分区：
文献类型：
--
作者：
Nosala,Christopher;Hagen,KariD;Dawson,ScottC
原生生物已经进化出无数高度特化的细胞骨架细胞器，这些细胞器扩展了微管（MT）聚合物的已知功能能力。其中一个创新-腹盘-是一个杯状的MT细胞器，寄生虫将其附着在宿主的小肠上。的分子机制的产生吸力为基础的部队的整体构象变化的光盘仍不清楚。精致的光盘架构是由新的蛋白质和复合物，装饰几乎所有的光盘MT原丝，并改变组成和构象沿着长度的MT定义。未来的遗传，生物化学和功能分析的光盘相关的蛋白质将是中央对理解不仅光盘的架构和组装，但也整体光盘构象动力学，促进附件。
Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation – the ventral disc – is a cup-shaped MT organelle that the parasiteGiardiauses to attach to the small intestine of its host. The molecular mechanisms underlying the generation of suction-based forces by overall conformational changes of the disc remain unclear. The elaborate disc architecture is defined by novel proteins and complexes that decorate almost all disc MT protofilaments, and vary in composition and conformation along the length of the MTs. Future genetic, biochemical, and functional analyses of disc-associated proteins will be central toward understanding not only disc architecture and assembly, but also the overall disc conformational dynamics that promote attachment.