Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease.
Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease.
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DOI：
10.1159/000337434
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发表时间：
2012
影响因子：
5.3
通讯作者：
Lee JS
中科院分区：
文献类型：
--
作者：
Lee JS
慢性阻塞性肺疾病（COPD）是一种因吸入香烟烟雾和其他有毒颗粒而产生异常炎症反应的疾病。肺部引发炎症和肺组织破坏的因素尚不完全清楚，但单核吞噬细胞通过释放促进炎症和组织破坏性肺气肿的介质发挥着核心作用。尽管关于肺泡巨噬细胞的长期香烟烟雾暴露及其对巨噬细胞极化模式的影响存在相互矛盾的研究，但我们最近在小鼠中发现了一种由 CX3CR1 表达定义的细胞类型，其群体在肺部扩张，并详细阐述了响应体内香烟烟雾暴露的 M1 特征细胞因子。此外，在长期接触香烟烟雾的小鼠模型中，功能性 CX3CR1 的缺失可以防止组织破坏性肺气肿。就免疫表型和功能而言，离散巨噬细胞亚群的异质性和可塑性可以解释看似不同的发现，一方面显示炎症特征受到抑制，另一方面炎症反应增强。本综述旨在研究离散单核吞噬细胞亚群响应香烟烟雾暴露而发展的证据，以及单核吞噬细胞所在的肺组织微环境提供的空间线索可能影响这些亚群的分布和功能。
Chronic Obstructive Pulmonary Disease (COPD) is a disease defined by an aberrant inflammatory response to inhaled cigarette smoke and other noxious particles. The factors triggered in the lungs that drive inflammation and lung tissue destruction are not fully understood, but mononuclear phagocytes play a central role by releasing mediators that promote both inflammation and tissue destructive emphysema. Although conflicting studies in alveolar macrophages exist regarding chronic cigarette smoke exposure and its effects on macrophage polarization patterns, we have recently identified a cell-type in mice defined by CX3CR1 expression whose population expands in the lungs and elaborates M1 signature cytokines in response to cigarette smoke exposure in vivo. In addition, the absence of functional CX3CR1 provides protection from tissue-destructive emphysema in a murine model of chronic cigarette smoke exposure. The heterogeneity and plasticity of discrete macrophage subsets, in terms of immuno-phenotype and function, may explain the seemingly disparate findings showing a suppressed inflammatory profile on the one hand and heightened inflammatory response on the other. This review proposes to examine the evidence that discrete mononuclear phagocyte subsets develop in response to cigarette smoke exposure, and the spatial cues provided by the lung tissue microenvironment in which the mononuclear phagocyte resides may influence the distribution and function of these subsets.
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影响因子：
64.5
作者：
DARMIENTO, J;DALAL, SS;CHADA, K
通讯作者：
CHADA, K
影响因子：
4.4
作者：
El-Shazly, A;Berger, P;Tunon-de-Lara, JM
通讯作者：
Tunon-de-Lara, JM
影响因子：
4.4
作者：
Chen, Haiyan;Cowan, Mark J.;Medvedev, Andrei E.
通讯作者：
Medvedev, Andrei E.
DOI：
10.1164/ajrccm.156.1.9612018
发表时间：
1997-07-01
影响因子：
24.7
作者：
Finlay, GA;ODriscoll, LR;OConnor, CM
通讯作者：
OConnor, CM
影响因子：
15.9
作者：
Bedoret, Denis;Wallemacq, Hugues;Bureau, Fabrice
通讯作者：
Bureau, Fabrice