Prevalence of psychiatric and substance use disorders in opioid abusers in a community syringe exchange program
Prevalence of psychiatric and substance use disorders in opioid abusers in a community syringe exchange program
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DOI：
10.1016/j.drugalcdep.2003.11.014
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发表时间：
2004-05-10
影响因子：
4.2
通讯作者：
Brooner, RK
中科院分区：
文献类型：
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作者：
Kidorf, M;Disney, ER;Brooner, RK
本研究评估了参加社区针头交换计划（NEP）的男性和女性静脉注射阿片类药物滥用者的精神和物质使用障碍的患病率。所有参与者（n = 422）都接受了针对I轴障碍和反社会人格障碍（APD）的DSM-IV （SCID）结构化临床访谈。精神疾病和药物滥用合并症非常普遍。重度抑郁症是最常见的当前和终生I轴非物质使用障碍（分别占样本的6%和21%）；37%被诊断为APD。超过50%的样本被诊断患有至少一种非物质使用I轴障碍或APD。除阿片类药物依赖外，可卡因依赖是最普遍的当前和终生物质使用障碍（分别占样本的68%和78%），其次是酒精和大麻依赖。总体而言，除了阿片类药物依赖外，参与者平均报告了一种以上的当前和三种以上的终生物质使用障碍。据报道，女性患创伤后应激障碍（PTSD）的比例更高，而男性更有可能被诊断为APD。精神障碍的存在与所有药物类别中物质使用障碍的患病率增加有关。在这个样本中观察到的高共病率表明，通过将参与者转介到治疗药物使用和/或其他精神疾病的项目中，可以显著提高新精神障碍患者减少伤害的努力。2004爱思唯尔爱尔兰有限公司版权所有。
The present study evaluates the prevalence of psychiatric and substance use disorders in male and female intravenous opioid abusers participating at a community needle exchange program (NEP). All participants (n = 422) were administered the Structured Clinical Interview for the DSM-IV (SCID) for Axis I disorders and antisocial personality disorder (APD). Psychiatric and substance abuse comorbidity were highly prevalent. Major depression was the most common current and lifetime Axis I non-substance use disorder (6 and 21 % of the sample, respectively); 37 % were diagnosed with APD. Over 50 % of the sample was diagnosed with at least one non-substance use Axis I disorder or APD. In addition to opioid dependence, cocaine dependence was the most prevalent current and lifetime substance use disorder (68 and 78 % of the sample, respectively), followed by alcohol and cannabis dependence. Overall, participants reported a mean of over one current and over three lifetime substance use disorders in addition to opioid dependence. Women reported higher rates of post-traumatic stress disorder (PTSD), while men were more likely diagnosed with APD. Presence of a psychiatric disorder was associated with increased prevalence of substance use disorder for all drug classes. The high rates of comorbidity observed in this sample suggest that the harm reduction efforts of NEPs can be significantly enhanced through referral of participants to programs that treat substance use and/or other psychiatric disorders. (C) 2004 Elsevier Ireland Ltd. All rights reserved.