POSITRON EMISSION TOMOGRAPHY IN ALZHEIMERS-DISEASE
POSITRON EMISSION TOMOGRAPHY IN ALZHEIMERS-DISEASE
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DOI：
10.1212/wnl.36.7.879
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发表时间：
1986-07-01
期刊：
影响因子：
9.9
通讯作者：
RAPOPORT, SI
中科院分区：
文献类型：
--
作者：
DUARA, R;GRADY, C;RAPOPORT, SI
使用正电子发射断层扫描（PET）和[18F]2 - 氟 - 2 - 脱氧 - D - 葡萄糖对21名临床诊断为阿尔茨海默病型痴呆（DAT）的患者以及29名年龄匹配的健康对照者进行了研究，以测量静息状态下局部大脑葡萄糖消耗情况。在轻度、中度和重度DAT组中，发现一些顶叶、颞叶和额叶区域的相对代谢比率指标降低。在轻度和中度组中还观察到右/左代谢不对称性显著增加，尤其是在顶叶区域。只有在重度痴呆患者中，大脑绝对代谢率才较对照组显著降低。14名患者进行了重复的PET研究，但只有那些中重度痴呆患者在6至15个月内智商下降。代谢指标随时间没有显著变化。PET在量化DAT的局部大脑功能障碍方面是有用的，即使在疾病的早期阶段也是如此。
Twenty-one patients with a clinical diagnosis of dementia of the Alzheimer''s type (DAT) and 29 healthy, age-matched controls were studied using positron emission tomography (PET) and [18F]2-fluoro-2-deoxy-D-glucose to measure regional cerebral glucose consumption in the resting state. Reductions in ratio measures of relative metabolism in some parietal, temporal, and frontal regions were found in mild, moderate, and severe DAT groups. A significant increase in right/left metabolic asymmetry, particularly in parietal regions, also was seen in mild and moderate groups. A significant increase in right/left metabolic asymmetry, particularly in parietal regions, also was seen in mild and moderate groups. Only in the severely demented patients was the absolute cerebral metabolic rate reduced significantly from control values. Fourteen patients had repeated PET studies, but only those patients with moderate to severe dementia showed a decline in IQ over 6 to 15 months. There were no significant changes in metabolic measures over time. PET is useful in quantifying regional cerebral dysfunction in DAT, even in the early stages of the disease.