Cadherins in cancer: implications for invasion and metastasis
Cadherins in cancer: implications for invasion and metastasis
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DOI：
10.1016/0955-0674(93)90029-p
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发表时间：
1993-10-01
影响因子：
7.5
通讯作者：
Takeichi, Masatoshi
中科院分区：
文献类型：
--
作者：
Takeichi, Masatoshi
为了了解转移的机制，必须首先确定癌细胞如何从原发性肿瘤中分离。钙粘蛋白是肿瘤和正常组织中主要的细胞间粘附分子。钙粘蛋白功能的紊乱导致肿瘤细胞暂时或永久性解聚，从而可能促进这些细胞的侵袭和转移。
In order to understand the mechanisms of metastasis, one must first determine how cancer cells detach from primary tumors. It is known that cadherins are major cell-cell adhesion molecules in tumors as well as in normal tissues. The perturbation of cadherin function causes temporal or permanent disaggregation of tumor cells and may thus promote the invasion and metastasis of such cells.