Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones.
Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones.
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胰岛素引起的严重低血糖与反调节激素释放不足有关。
DOI：
10.1056/nejm198111123052007
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Owen,OE
中科院分区：
文献类型：
--
作者：
Boden,G;ReichardJr,GA;Hoeldtke,RD;Rezvani,I;Owen,OE
血糖下降到低血糖水平通常会触发儿茶酚胺、胰高血糖素、生长激素和皮质醇的迅速释放。这些所谓的反调节激素被认为通过增加肝脏葡萄糖的产生（在胰高血糖素、肾上腺素和皮质醇的情况下）或通过减少外周葡萄糖的使用（在肾上腺素和生长激素的情况下）将血糖恢复到正常浓度。然而，在对抗胰岛素诱导的低血糖中，各个激素的相对作用还没有建立。在本文中，我们报告了一个胰岛素依赖型糖尿病患者的病例，他能够合成和释放所有的反调节激素。
A FALL in blood glucose to hypoglycemic levels usually triggers a prompt release of catecholamines, glucagon, growth hormone, and cortisol. These so-called counterregulatory hormones are believed to restore blood glucose to normal concentrations by increasing hepatic glucose production (in the cases of glucagon, epinephrine, and cortisol) or by decreasing peripheral use of glucose (in the cases of epinephrine and growth hormone). The relative contributions of the individual hormones in counteracting insulin-induced hypoglycemia, however, have not been established.In this paper, we report the case of an insulin-dependent diabetic patient who was capable of synthesizing and releasing all the counterregulatory hormones . . .