THE EFFECT OF INDUCED HYPOTHERMIA UPON OXYGEN CONSUMPTION IN THE RAT BRAIN
THE EFFECT OF INDUCED HYPOTHERMIA UPON OXYGEN CONSUMPTION IN THE RAT BRAIN
复制标题
诱导低温对大鼠脑耗氧量的影响
DOI：
--
复制
发表时间：
1975
影响因子：
4.7
通讯作者：
B. K. Siesjöu
中科院分区：
文献类型：
--
作者：
M. Hägerdal;J. Harp;L. Nilsson;B. K. Siesjöu
在氧化亚氮麻醉的人工通气大鼠上研究了低温对脑氧代谢率（CMRO 2）的影响。脑血流量的测量采用改进的凯蒂和施密特技术，使用133氙。发现CMRO 2在37°C-22°C的温度范围内随温度线性降低。在正常温度下，CMRO 2每摄氏度下降约5%。在体温为22°C时，脑血流量和CMRO 2都减少到正常值的25%左右。
The effect of hypothermia upon cerebral metabolic rate for oxygen (CMRO2) was studied in artificially ventilated rats, anaesthetized with nitrous oxide. Cerebral blood flow was measured with a modification of the Kety and Schmidt technique using 133xenon. CMRO2, was found to decrease linearily with temperature in the temperature range 37°C‐22°C. At normal temperatures CMRO2, fell by about 5 per cent per degree C. At a body temperature of 22°C both cerebral blood flow and CMRO2, were reduced to about 25 per cent of normal.