GASTRIC CANCER IN COLOMBIA .1. CANCER RISK AND SUSPECT ENVIRONMENTAL AGENTS
GASTRIC CANCER IN COLOMBIA .1. CANCER RISK AND SUSPECT ENVIRONMENTAL AGENTS
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DOI：
10.1093/jnci/57.5.1015
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发表时间：
1976-01-01
影响因子：
10.3
通讯作者：
TANNENBAUM
中科院分区：
文献类型：
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作者：
CUELLO, C;CORREA, P;TANNENBAUM
一项对出院患者的病例对照研究显示，在纳里尼奧省（哥伦比亚），胃癌风险的地理变异存在4倍差异。对人口群体进行胃镜检查的数据、纳里尼奧供水和尿液及唾液样本也表明，下列参数之间存在正相关：胃癌风险、慢性萎缩性胃炎和肠上皮化生的患病率、井水的硝酸盐含量和人口的硝酸盐排泄量。尿液排泄反映了硝酸盐的摄入，这意味着胃癌高危人群中硝酸盐的平均摄入量较高。纳里尼奧的数据可以解释为硝酸盐利用率在胃癌病因学中的作用的假定流行病学证据。
A case-control study of patients discharged from hospitals revealed 4-fold differences in geographic variation in stomach cancer risk within the Department of Narino (Colombia). Data from gastroscopic surveys of population groups, samples of water supplies and urine and saliva in Narino also indicated a positive correlation among the following parameters: gastric cancer risk, prevalence of chronic atrophic gastritis and intestinal metaplasia, nitrate content of well water and nitrate excretion by the population. Urinary excretion reflected the ingestion of nitrates, and this implied a higher average intake of nitrates in the populations at high risk for stomach cancer. The Narino data could be construed as presumptive epidemiologic evidence for the role of nitrate availability in the etiology of stomach cancer.